THE DISTRIBUTION OF INTRAVENOUSLY ADMINISTERED YTTRIUM CHLORIDE (CARRIER FREE) IN THE RHESUS MONKEY

Journal Article · Wed May 01 00:00:00 EDT 1963 · Toxicology and Applied Pharmacology (U.S.)

DOI:https://doi.org/10.1016/0041-008X(63)90092-9· OSTI ID:4657666

Diagneault, E A

The biologic handling of Y is of some importance since Y/sup 90/ is being used increasingly in radiotherapy. Thus a study was made of the distribution of Y after intravenous administration of carrier-free Y/sup 91/Cl/ sub 3/ in the rhesus monkey to compare the results with those obtained in other species. The response of zymosan-pretreated monkeys to intravenous Y was also studied. Y in the blood is cleared rapidly; its haif life is 10 min. After injection of 80 mu C/kg, highest concentration of Y occurs in femur, liver, intestine, kidney, and skull bone. Less active but with values exceeding that of blood at the time of sacrifice are lung, adrenal, spleen, thyroid, and heart, with practically no Y in brain and thymus. A comparison of the rat and mouse data with data of the monkey shows they are closely parallel, except that the mouse differs by exhibiting a high lung and spleen concentration. The excretion of Y during a 4-hour interval shows that a substantial amount is excreted in urine and a small amount in the bile. Feces did not contain any measurable activity during this interval. In rat and mouse the predominant excretion is also via the urine. Intravenous administration of zymosan, 25 mg/kg 3 days prior to administration of Y, produced no enthancement of the blood clearance. The observed half life value of 12.0 min was not significantly different from the control value. Y tissue distribution was not affected by the more active reticuloendothelial system; the active ratio in the liver actually decreased. Mice and rats, however, did respond to zymosan with the expected enhanced concentration of Y in the liver and spleen. Excretion of Y by the pretreated monkeys was not depressed. The other two species which did respond to zymosan treatment excreted less Y than the control, as expected. In accord with the results of tissue analysis, study of the gross autoradiograms revealed no difference between the treated and nontreated. Cross-section of the femur shaft showed that the marrow had no significant activity, and activity that was present was located in the periosteum, Distribution in the liver and spleen was generalized whereas in the lung, kidney, adrenal, and femur it was more selective. The brain was devoid of Y. The rat tissue autoradiograms showed similar results. Lack of activity in the brain indicates that Y is unable to penetrate the blood brain barrier. The pattern of deposition of Y in the rhesus monkey agrees well with that reported for the rabbit, guinea pig, and man, and show a closer similarity to the rat than the mouse. (BBB)

• Research Organization: Louisiana State Univ., New Orleans
• NSA Number: NSA-17-038729
• OSTI ID: 4657666
• Journal Information: Toxicology and Applied Pharmacology (U.S.), Vol. Vol: 5; Other Information: Orig. Receipt Date: 31-DEC-63
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
ADRENAL GLANDS
BARRIERS
BILE
BLOOD
BONE MARROW
BONES
BRAIN
DIFFUSION
DISTRIBUTION
DRUGS
ENZYMES
FECES
FLUIDS
GUINEA PIGS
HEART
INTESTINE
KIDNEYS
LABELLED COMPOUNDS
LIVER
LUNGS
LYMPH SYSTEM
MAN
METABOLISM
MICE
MONKEYS
QUANTITY RATIO
RABBITS
RADIOACTIVITY
RADIOAUTOGRAPHY
RADIOTHERAPY
RATS
RETICULOENDOTHELIAL SYSTEM
SPLEEN
THYMUS
THYROID
TISSUES
URINE
USES
YTTRIUM 90
YTTRIUM 91
YTTRIUM CHLORIDES
ZYMOSAN