4-[F-18]fluoroproline: A potential tracer for collagen synthesis. Radiosynthesis and biological evaluation

Journal Article · Wed May 01 00:00:00 EDT 1996 · Journal of Nuclear Medicine

OSTI ID:447726

Hamacher, K ^[1]; Herz, M; Truckenbrodt, R ^[2]

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1. Institut fuer Nuklearchemie, KFA Juelich (Germany)
2. Nuklearmedizinische Klinik der TU Muenchen (Germany); and others

Proline is an important constituent of the structural protein collagen. It has been shown that its fluorinated analogs (2S,4S)- and particularly (2S,4R)-4-fluoroproline are also incorporated into collagen (Gottlieb et al., Biochemistry (1965), 4: 2507). 4-[F-18]fluoroproline is therefore a potential probe for studying abnormal collagen synthesis e. g. in tumors, lung fibrosis and liver cirrhosis. We have evaluated the two diastereomeric forms using a transplantable osteosarcoma in mice as an in vivo model for elevated collagen synthesis, and a MCF 7 mamma carcinoma cell line for monolayer incubation studies.

• OSTI ID: 447726
• Report Number(s): CONF-960659-; ISSN 0161-5505; TRN: 97:000961-0006
• Journal Information: Journal of Nuclear Medicine, Vol. 37, Issue Suppl.5; Conference: 43. annual meeting of the Society of Nuclear Medicine, Denver, CO (United States), 3-6 Jun 1996; Other Information: PBD: May 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
COLLAGEN
BIOSYNTHESIS
PROLINE
UPTAKE
FLUORINE 18
ORGANIC FLUORINE COMPOUNDS
FIBROSIS
FLUORINATION
IN VIVO
LIVER CIRRHOSIS
MICE
LABELLED COMPOUNDS
TRACER TECHNIQUES
CARCINOMAS
NEOPLASMS
POSITRON COMPUTED TOMOGRAPHY