Transport of radioactively labeled proteins in the visual system of the chick
The transport of proteins synthesized in the somata of retinal ganglion cells of 3 to 5 week-old chicks was studied autoradiographically and by liquid scintillation counting following the intravitreal injection of 3H-leucine or 3H- proline. Most of the transported proteins move with a velocity of 1.5 to 2 mm/ day and are distributed throughout the extent of the optic nerve and to the various diencephalic and mesencephalic structures to which it sends fibers. A relatively small proportion of the transported material has a rate of approximately 200 mm/day and is preferentially (but not exclusively) distributed to the region of the axon terminals. The differential distribution of the two components is readily demonstrated by grain counts in autoradiographs of the optic tectum: the rapid phase clearly labels the outer laminae of the stratum griseum et fibrosum superficiale in which the retinal fibers terminate very heavily, whereas the arrival of the slow phase results in an increasing grain density over the optic nerve fibers in the stratum opticum. (INIS)
- Research Organization:
- Washington Univ., St. Louis
- NSA Number:
- NSA-29-002966
- OSTI ID:
- 4421948
- Journal Information:
- Brain Res., v. 56, pp. 77-105, Other Information: Orig. Receipt Date: 30-JUN-74
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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