Head malformation induced by x rays and 5-fluoro-2'-deoxycytidine (FCdR) in mice inbreeding strain C57BL/6Ffm. Comparative investigation under the consideration of dose-response relationships

Thesis/Dissertation · Fri Jan 01 00:00:00 EST 1971

OSTI ID:4394963

Emmerich, W

Thesis. On the mouse inbreeding strain, malformations of the skeleton of the head of fetuses were investigated with x rays and FCdR. The frequeney and mark of various malformations depend on the amount of the dose given. the induction time, the type of the teratogenic agent, and the genotype of the strain. Basically however, the various malformations could neither be definitely determined between the x-ray irradiation series nor between the x-ray and FCdR test series. At thc same absorption rates, the teratogenic effect in the FCdR test series was smaller than in the x-ray series. Contrary to the x-ray series, a doubling of the dose in the FCdR test series often showed no increase in the frequency of disorders. Serious malformations (cranioschisis and otocephy in the narrower sense) could be observed even with the smallest doses investigated. (GE)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-29-000700
• OSTI ID: 4394963
• Resource Relation: Other Information: Thesis. Orig. Receipt Date: 30-JUN-74; Bib. Info. Source: GE (GE)
• Country of Publication: Germany
• Language: German

Related Subjects

N48520* -Life Sciences-Radiation Effects on Animals- Vertebrates
*FETUSES- BIOLOGICAL RADIATION EFFECTS
*HEAD- MALFORMATIONS
*MALFORMATIONS- RADIOINDUCTION
*NUCLEOSIDES- TOXICITY
*ORGANIC FLUORINE COMPOUNDS- TOXICITY
*PYRIMIDINES- TOXICITY
ANTIMITOTIC DRUGS
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
LOW DOSE IRRADIATION
MICE
PHOTON BEAMS
PRENATAL IRRADIATION
X RADIATION