OBSERVATIONS FOLLOWING EXPERIMENTAL INTRALARYNGEAL INJECTION OF RADIOISOTOPES (CrP$sup 32$$O$$sub 4$ Cr$sup 51$$P$$sup 32$$O$$sub 4$)
Radioactive chromic phosphate tagged with radiochromnium and radiophosphorous was introduced in varying concentrations by multiple injections and its spread throughout the larynx observed. The larynx was scanned at selected intervasl up to eight weeks. If injected on only one side of the larynx no crossover to the opposite side took plane within this period. Studies were made of the fate of the injected isotope. Small amounts appeared in thc blood stream in a matter of minutes but this cleared in a few hours. No spread -downwards into the trachea was observed. Within 24 hours after injection, counts taken o ver the larynx inof the body of approximately 25%. Part of this fraction was recovered in the lymph nodes of the neck andd smaller fractons in the liver and spleen. No further loss of radioactivity was noted during the next eight weeks. Radioactivity in appreciable amount remained in the lymph nodes- of the neck for this period of observation but more was observed in other adjacent tissues. Essentially all the injected material has been accounted for and its fate in the body will be described. The smallest amount of radioactive isotope considered can0 cerocidal i.e., approximately 10,000 rem per gram of tissue was well tolerated by the dog;s larynx. When the concentraion was increased to as much as 60,000 rem per gram, ulceration and necrosis often amounting to complete destruction, occured, Studies of the effects of intermediate dosages are in progress. Certain details of the observed spread of injected fluids including radioisotopes resulted in the observation that the larynx was divided into submucosal compartments essentially independent of each other. This required that pattern of injection by areas be developed to assure for purposes of therapy, the proper dissemination of radioisotopes. This pattern and suggested dosage for clinical trials are describe and illustrate by slides. The patterns of submucosal compartmentation as observed in these studies, when correlated with the clinical distribution of cancer of the larynx, suggest that on the basis of these finds the local route of spread of cancer of the larynx can be predicted. These studles with radioisotopes have been confined by the use of dyes, permitting visual mately 150 dogs were used in the experiments which were augmented by observations on a few humans and in experimental pigs. (auth)
- Research Organization:
- California. Univ., Los Angeles
- NSA Number:
- NSA-12-014581
- OSTI ID:
- 4309927
- Report Number(s):
- A/CONF.15/P/865
- Resource Relation:
- Other Information: Prepared for the Second U.N. International Conference on the Peaceful Uses of Atomic Energy, 1958. Orig. Receipt Date: 31-DEC-58
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
BLOOD CIRCULATION
BODY
CHROMIUM 51
CHROMIUM PHOSPHATES
CONFERENCE
COUNTERS
DETECTION
DISTRIBUTION
DOGS
LABELLED COMPOUNDS
LARYNX
LIQUIDS
LIVER
LYMPH NODES
LYMPH SYSTEM
NECROSIS
PHOSPHORUS 32
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
RADIOACTIVITY
RADIOTHERAPY
SPLEEN
TISSUES
ULCERS
VARIATIONS