TRANSFER OF DONOR IMMUNOLOGICAL REACTIVITY TO X-IRRADIATED F$sub 1$ HYBRID MICE BY INJECTED PARENTAL BONE MARROW
Mice of the (LxA)F/sub 1/ strain were exposed to an LD/sub 100/ dose of x rays and injected with bone marrow cell suspensions from A-strain mice. Excellent protection against death was observed during the first 3 weeks, followed by secondary homologous deaths during the ensuing weeks. When A-strain spleen cells were injected, together with A-straln bone marrow, then protective effect was annulled. When A-spleen cells were injected together with LAF/sub 1/ bone marrow cells into irradiated LAF/sub 1/ mice, again no protection was observed. However, injected LAF/sub 1/ spleen cells did not influence adversely the course of protection of x-irradiated Astrain mice by injected A-bone marrow. The findings formed the basis for an experimeatal test system for detecting the presence of A-lymphoid cells in the tissues of irradiated LAF/sub 1/ mice which had been injected with A-bone marrow. The data indicate that the spleen and thymus of LAF/sub 1/ mice 21 days after irradiation and injection of A-marrow contain A-lymphoid cells which when injected, in turn, into irradiated LAF/sub 1/ mice treated with LAF/sub 1/ marrow, annuls the protective effect of the injected marrow. It is concluded that a reaction of an immunological nature of the injected bone marrow cells, or their progeny, against the host tissues, contributes to the phenomenon of the late deaths. The significance of these results with respect to the problem of homologous disease in lethally x- irradiated mice treated with homologous bone marrow is discussed. (auth)
- Research Organization:
- U.S. Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-13-004399
- OSTI ID:
- 4302740
- Journal Information:
- American Journal of Physiology (U.S.), Vol. Vol: 196; Other Information: Orig. Receipt Date: 31-DEC-59
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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