SEMIANNUAL REPORT TO THE ATOMIC ENERGY COMMISSION
Data are summarized from a series of recently published papers which indicate that the tissue iron enzymes as well as the blood hemoglobin level play a role in the iron-deficiency state. Results from a study of the derivation, roles and fate of the antibody-forming cell in the rat indicate that antibody- forming cells in lymph nodes may be released to circulate in the efferent lymph and peripheral blood. Evidence indicates that the circulating cells may still contain formed antibody. Because of thcir form these circulating elements are designated lymphocytes. Strong evidence also implicates the plasma cell in the immune phenomenon. It appears that thc circulating blood contains two small round cells, one produced in the germinal centers of the spleen and other lymphatic tissue and having no known relationship to antibody production, while the other is apparently produced in the splenic red pulp, contains antibody, and is related intimately to antibody synthesis. In terms of site of production and function the two cells appear unrelated. Papers included which have been accepted for publication cover the effect of concurrent feeding of Tween 80 on the carcinogenicity of orally-administered 3-methylcholanthrene, data on the long- term survival of irrailiated mice treated with homologous tissue suspensions, a new modality in brachytherapy based on isotopes decaying by electron capture, the distribution of intraperitoneal radiocolloids, acquired tolerance to mouse leukemia in rats, and the determination of metabolites of cardiac glycosides in human urine. A list of staff publications during the period is included. (For preceding period see ACRH-10.) (C.H.)
- Research Organization:
- Argonne Cancer Research Hospital, Chicago
- DOE Contract Number:
- AT(11-1)-69
- NSA Number:
- NSA-13-014957
- OSTI ID:
- 4243323
- Report Number(s):
- ACRH-11
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-59
- Country of Publication:
- United States
- Language:
- English
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