Modifications to Lipids and Some Other Constituents of the Liver of the Guinea Pig Caused by X Radiation (thesis); MODIFICATIONS APPORTEES PAR L'IRRADIATION X AUX LIPIDES ET A QUELQUES AUTRES CONSTITUANTS DU FOIE DE COBAYE (THESE)
The effect of whole-body and local x radiation on the lipids, proteins, and glycogen of the liver of guinea pigs was systematically studied on males aged 5 to 7 months. The experimental techniques and the analytical methods used were described. The control guinea pigs were fed exactly the same diet in quality and quantity as the irradiated animals. The composition of the normal and fasting guinea pig was determined before the irradiation studies. Whole-body irradiation with a lethal dose in a single dose or over a period of several weeks led to the appearance of an enlarged liver. Biochemical analysis showed that the glyceride overcharge is moderated, the glycogen modifications were concomitant with those of lipids, and the total quantity of proteins increased. Irradiation of the head with a sublethal dose did not affect the composition of the liver. Lethal doses caused an intense glyceride-enlarged liver. Three to six months after local irradiation on the hepatic region or after single-dose or fractionated whole-body irradiation, late steatosis appeared and seemed to be the only direct effect of x radiation on the hepatic cells. The acute hepatic modifications had an external origin. The most toxic form of irradiation was whole-body irradiation in fractionated doses. (J.S.R.)
- Research Organization:
- Paris. Universite
- NSA Number:
- NSA-18-015813
- OSTI ID:
- 4062711
- Report Number(s):
- NP-13733
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-64
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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