PROPOSAL TO INVESTIGATE THE CHANGE IN URINARY CONSTITUENTS AS A MEASURE OF RESPONSE TO WHOLE BODY IRRADIATION. Oct. 20, 1960. (KN-60-652(P). Includes Reports: KN-60-652(CP): COST PROPOSAL TO INVESTIGATE THE CHANGE IN URINARY CONSTITUENTS AS A MEASURE OF RESPONCE TO WHOLE BODY IRRADIATION. Oct. 20, 1960. KN-60-673-A(P): PROPOSAL TO INVESTIGATE THE CHANGE IN URINARY CONSTITUENT
Various physiological modifications following gamma radiation were examined. Emphasis was placed on those which may be caused by, or aided by, alteration in degree of endocrine activity. An attempt was made to correlate the modifications with dosage or gross physical effects. Young, male, Charles River rats were exposed to wholebody doses of 0.25, 2.8, 29, 289, 729, 763, 804, 842, and 1040 rads of Co/sup 60/ radiation. The urines were analysed in particular for calcium, phosphate, and urea content. It was found that other stress induction modifies the response, but that the change induced by irradiation is still clearly indicated. The values for the first 24 hours after exposure were clearly grouped into those that will survive for 30 days post irradiation and those that will die within the 30 day period. Those that die have a high excretion rate of the measured constituents and those that survive have a marked retention. The responses measured clearly begin at levels as low as 2.8 rads. (auth)
- Research Organization:
- Kaman Aircraft Corp. Kaman Nuclear Div., Colorado Springs
- NSA Number:
- NSA-15-019139
- OSTI ID:
- 4006511
- Report Number(s):
- NP-10175
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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