Bioaccumulation and MFO enzyme induction of di, tri- and tetrachlorodibenzofurans and 2,3,7,8-TCDD in juvenile rainbow trout
- Department of Fisheries and Oceans, Winnipeg, Manitoba (Canada). Freshwater Inst.
Juvenile rainbow trout (3--10 g) were exposed to dietary 2,8-di-, 2,3,8-tri-, and 2,3,7,8-tetrachlorodibenzofuran (TCDF) and to 2,3,7,8-TCDD in separate experiments. Elimination was studied for up to 180 days following a 30 days exposure. The authors compared the MFO induction potency, assimilation efficiencies, biomagnification factors and elimination rates of di and trichlorofurans, which are the major PCDD/F congeners in bleached (partial ClO{sub 2} substitution) kraft pulp mill effluent, with those of TCDD/F. 2,8-D{sub 2}CDF and 2,3,8,-T{sub 3}CDF were rapidly eliminated with half-lives (t{sub 1/2}) of 6 to 1 0 days for both compounds. By contrast TCDF and TCDD were slowly eliminated by the trout (t{sub 1/2} = 70 and 80 d, respectively). Biomagnification factors for 2,8-D{sub 2}CDF and 2,3,8,-T{sub 3}CDF were < 0.1 and there was evidence of extensive transformation of T{sub 3}CDF to polar degradation products. P450 MFO (EROD) activities in fish exposed to 100 or 300 ng/g of 2,3,8,-T{sub 3}CDF were 5 to 15-fold elevated (over controls); 2,8-D{sub 2}CDF exposure had no effect. Exposure to 413 pg/g TCDD in food resulted in 4-fold elevation in EROD after 30 days corresponding to a concentration in muscle of 120 pg/g wet wt. MFO activity returned to control levels 24 days after cessation of exposure to 2,3,8,-T{sub 3}CDF and 120 days after exposure to TCDD.
- OSTI ID:
- 40029
- Report Number(s):
- CONF-9410273-; TRN: IM9520%%224
- Resource Relation:
- Conference: 15. annual meeting of the Society of Environmental Toxicology and Chemistry (SETAC), Denver, CO (United States), 30 Oct - 3 Nov 1994; Other Information: PBD: 1994; Related Information: Is Part Of Society of Environmental Toxicology and Chemistry 15th annual meeting: Abstract book. Ecological risk: Science, policy, law, and perception; PB: 286 p.
- Country of Publication:
- United States
- Language:
- English
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