A 2D smart pixel detector for time resolved protein crystallography

Journal Article · Sat Jun 01 00:00:00 EDT 1996 · IEEE Transactions on Nuclear Science

DOI:https://doi.org/10.1109/23.506671· OSTI ID:277646

Beuville, E; Cork, C; Earnest, T ^[1]

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1. Lawrence Berkeley National Lab., CA (United States); and others

A smart pixel detector is being developed for Time Resolved Crystallography for biological and material science applications. Using the Pixel Detector presented here, the Laue method will enable the study of the evolution of structural changes that occur within the protein as a function of time. The x-ray pixellated detector is assembled to the integrated circuit through a bump bonding process. Within a pixel size of 150x150 {micro}m{sup 2}, a low noise preamplifier-shaper, a discriminator, a 3 bit counter and the readout logic are integrated. The read out, based on the Column Architecture principle, will accept hit rates above 5{times}10{sup 8}/cm{sup 2}/s with a maximum hit rate per pixel of 1 MHz. The detector will allow time resolved Laue crystallography to be performed in a frameless operation mode, without dead time. Target specifications, architecture and preliminary results on the 8x8 front-end prototype and the column readout are presented.

• OSTI ID: 277646
• Report Number(s): CONF-951073-; ISSN 0018-9499; TRN: 96:018099
• Journal Information: IEEE Transactions on Nuclear Science, Vol. 43, Issue 3Pt2; Conference: IEEE nuclear science symposium and medical imaging conference, San Francisco, CA (United States), 21-28 Oct 1995; Other Information: PBD: Jun 1996
• Country of Publication: United States
• Language: English

Related Subjects

44 INSTRUMENTATION
INCLUDING NUCLEAR AND PARTICLE DETECTORS
55 BIOLOGY AND MEDICINE
BASIC STUDIES
PROTEINS
CRYSTALLOGRAPHY
X-RAY DETECTION
RADIATION DETECTORS
DESIGN
MORPHOLOGICAL CHANGES
LAUE METHOD
PULSE SHAPERS
PULSE DISCRIMINATORS
READOUT SYSTEMS
CHARGE-COUPLED DEVICES
INTEGRATED CIRCUITS
SEMICONDUCTOR DIODES