Characterization and mapping of the Rapsn gene encoding the 43-kDa acetylocholine receptor-associated protein

Journal Article · Tue Nov 15 00:00:00 EST 1994 · Genomics

DOI:https://doi.org/10.1006/geno.1994.1629· OSTI ID:250267

Gautam, M; Mudd, J; Copeland, N G ^[1]

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1. Washington Univ. Medical School, St Louis, MO (United States); and others

The authors have cloned and characterized mouse genomic DNA containing the gene for the 43-kDa acetylcholine receptor-associated protein. The gene extends over 12 kb and consists of 8 exons. RNase protection and sequence analysis have been used to define the intron/exon boundaries including 174 and 214 bp of 5{prime} and 3{prime} untranslated sequence in exons 1 and 8, respectively. Interestingly, the exon/intron organization is consistent with structural domains predicted from amino acid sequence conservation among 3 species of 43K. Finally, the 43K locus, designated Rapsn, has been mapped to the central region of mouse chromosome 2. 11 refs., 2 figs.

• OSTI ID: 250267
• Journal Information: Genomics, Vol. 24, Issue 2; Other Information: PBD: 15 Nov 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
RECEPTORS
GENES
CHROMOSOMES
GENETIC MAPPING
CENTRAL NERVOUS SYSTEM