Prediction of chemical biotransfer of organic chemicals from cattle diet into beef and milk using the molecular connectivity index
- Univ. of California, Davis, CA (United States)
Biotransfer factors (BTFs) represent the ratio of the concentration of a chemical found in animal tissues such as beef or milk to the animal`s daily intake of that chemical. Using currently available citations for BTFs in meat and milk, the use of molecular connectivity indices (MCIs) as a quantitative structure reactivity relationship (QSAR) for predicting the BTFs for organic chemicals is evaluated. Based on a statistical evaluation of correlation, residual error, and cross validation, this evaluation reveals that the MCI provides both higher reliability and a fast and cost-effective method for predicting the potential biotransfer of a chemical from environmental media into food. When compared to the use of K{sub ow} as a predictor of BTFs, the analysis here indicates that MCI can substantially increase the reliability with which BTFs can be estimated. 66 refs., 2 figs., 3 tabs.
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 232452
- Journal Information:
- Environmental Science and Technology, Vol. 30, Issue 3; Other Information: PBD: Mar 1996
- Country of Publication:
- United States
- Language:
- English
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