Reverse triiodothyronine (rT3) attenuates ischemia-reperfusion injury
- Dept. of Zoology, BR Ambedkar University, Lucknow (India)
- Dept of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow (India)
- Dept. of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow (India)
Highlights: • rT3 mitigates IR injury in vivo. • rT3 mitigates IR injury in vitro. • rT3 reduced IR induced oxidative stress. Hypothyroidism has been associated with better recovery from cerebral ischemia-reperfusion (IR) injury in humans. However, any therapeutic advantage of inducing hypothyroidism for mitigating IR injury without invoking the adverse effect of whole body hypothyroidism remains a challenge. We hypothesize that a deiodinase II (D2) inhibitor reverse triiodothyronine (rT3) may render brain specific hypometabolic state to ensue reduced damage during an acute phase of cerebral ischemia without affecting circulating thyroid hormone levels. Preclinical efficacy of rT3 as a neuroprotective agent was determined in rat model of middle cerebral artery occlusion (MCAO) induced cerebral IR and in oxygen glucose deprivation/reoxygenation (OGD/R) model in vitro. rT3 administration in rats significantly reduced neuronal injury markers, infarct size and neurological deficit upon ischemic insult. Similarly, rT3 increased cellular survival in primary cerebral neurons under OGD/R stress. Based on our results from both in vivo as well as in vitro models of ischemia reperfusion injury we propose rT3 as a novel therapeutic agent in reducing neuronal damage and improving stroke outcome.
- OSTI ID:
- 23137252
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 506, Issue 3; Other Information: Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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