Validation of Calibration Parameters for Trapped Ion Mobility Spectrometry

Journal Article · Tue Oct 15 00:00:00 EDT 2019 · Journal of the American Society for Mass Spectrometry

DOI:https://doi.org/10.1007/S13361-019-02289-1· OSTI ID:22925070

Naylor, Cameron N.; Reinecke, Tobias ^[1]; Ridgeway, Mark E.; Park, Melvin A. ^[2]

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1. Washington State University, Department of Chemistry (United States)
2. Bruker Daltonics Inc. (United States)

Using contemporary theory for ion mobility spectrometry (IMS), gas-phase ion mobilities within a trapped ion mobility-mass spectrometer (TIMS) are not easily deduced using first principle equations due to non-linear pressure changes and consequently variations in E/N. It is for this reason that prior literature values have traditionally been used for TIMS calibration. Additionally, given that verified mobility standards currently do not exist and the that the exact conditions used to measure reported literature values may not always represent the environment within the TIMS, a direct approach to validating the behavior of the TIMS system is warranted. A calibration procedure is presented where an ambient pressure, ambient temperature, two-gate, printed circuit board drift-tube IMS (PCBIMS) is coupled to the front of a TIMS allowing reduced mobilities to be directly measured on the same instrument as the TIMS. These measured mobilities were used to evaluate the TIMS calibration procedure which correlates reduced mobility and TIMS elution voltages with literature values. When using the measured PCBIMS-reduced mobilities of tetraalkyl ammonium salts and tune mix for TIMS calibration of the alkyltrimethyl ammonium salts, the percent error is less than 1% as compared with using the reported literature K{sub 0} values where the percent error approaches 5%. This method provides a way to obtain accurate reference mobilities for ion mobility techniques that require a calibration step (i.e., TIMS and TWAVE). .

• OSTI ID: 22925070
• Journal Information: Journal of the American Society for Mass Spectrometry, Vol. 30, Issue 10; Other Information: Copyright (c) 2019 American Society for Mass Spectrometry; Country of input: International Atomic Energy Agency (IAEA); ISSN 1044-0305
• Country of Publication: United States
• Language: English

Related Subjects

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
CALIBRATION
COMPARATIVE EVALUATIONS
DRIFT TUBES
ION MOBILITY
MASS SPECTROMETERS
MASS SPECTROSCOPY
NONLINEAR PROBLEMS