Structure, magnetic and cytotoxic behaviour of solvothermally grown Fe3O4@Au core-shell nanoparticles
- Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, Santiago de Querétaro, Qro. 76230 (Mexico)
- Instituto de Física, Benemérita Universidad Autónoma de Puebla, Apdo. Postal J-48, Puebla, Pue. 72570 (Mexico)
Highlights: • Synthesis of Fe{sub 3}O{sub 4}@Au nanoparticles was made by solvothermal method. • The magnetic nanoparticles was analyzed by XRD, FT-IR, magnetization curves and aberration corrected (Cs) STEM techniques. • Core-shell Fe{sub 3}O{sub 4}@Au nanoparticles showed low apoptotic response and therefore lower toxicity. • Fe{sub 3}O{sub 4}@Au nanoparticles with high saturation magnetization showed good biocompatibility. - Abstract: Magnetic nanoparticles (MNPs) have demonstrated their potential in a wide variety of biomedical applications including in tumour hyperthermia. However, highly reactive nature and aggregation affinity of these nanostructures are the principal limitations for such applications. To overcome these limitations, those MNPs should be covered with an inert shell in order to protect the magnetic core against chemical alterations. Considering the noble, chemically inert nature of gold, which also has good biocompatibility, we fabricated chemically stable gold-coated Fe{sub 3}O{sub 4} (Fe{sub 3}O{sub 4}@Au) nanoparticles of 20–50 nm size range with considerable saturation magnetization, though a simple one-pot solvothermal method. The morphology, elemental distribution and the structure of the core-shell nanoparticles were characterized using aberration-corrected (Cs) Scanning transmission electron microscopy (STEM), and compared with their simulated images. Cytotoxicity assay in MDCK cell line was performed to evaluate the biocompatibility of the nanoparticles. The results showed higher cell viability for the Fe{sub 3}O{sub 4}@Au nanoparticles, suggesting their good biocompatibility and potentials for biomedical applications.
- OSTI ID:
- 22805080
- Journal Information:
- Materials Characterization, Vol. 142; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 1044-5803
- Country of Publication:
- United States
- Language:
- English
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