Silicon nanoparticles as contrast agents in the methods of optical biomedical diagnostics

Journal Article · Tue Aug 01 00:00:00 EDT 2017 · Quantum Electronics (Woodbury, N.Y.)

DOI:https://doi.org/10.1070/QEL16380· OSTI ID:22725970

Zabotnov, S. V.; Kashaev, F. V.; Shuleiko, D. V.; Gongalsky, M. B.; Golovan, L. A.; Kashkarov, P. K.; Loginova, D. A.; Agrba, P. D.; Sergeeva, E. A.; Kirillin, M. Yu.

The efficiency of light scattering by nanoparticles formed using the method of picosecond laser ablation of silicon in water and by nanoparticles of mechanically grinded mesoporous silicon is compared. The ensembles of particles of both types possess the scattering coefficients sufficient to use them as contrast agents in optical coherence tomography (OCT), particularly in the range of wavelengths 700 – 1000 nm, where the absorption of both silicon and most biological and mimicking tissues is small. According to the Mie theory the main contribution to the scattering in this case is made by the particles having a relatively large size (150 – 300 nm). In the experiments on visualising the agar phantom surface by means of OCT, the contrast of the medium boundary, provided by nanoparticles amounted to 14 dB and 30 dB for the ablated particles and the porous silicon powder, respectively. The numerical simulation of OCT images of skin in the presence of nanoparticles, confirmed the efficiency of using them as a contrast agent. (nanoparticles)

• OSTI ID: 22725970
• Journal Information: Quantum Electronics (Woodbury, N.Y.), Vol. 47, Issue 7; Other Information: Country of input: International Atomic Energy Agency (IAEA); ISSN 1063-7818
• Country of Publication: United States
• Language: English

Related Subjects

75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
62 RADIOLOGY AND NUCLEAR MEDICINE
ABLATION
ABSORPTION
AGAR
ANIMAL TISSUES
COMPUTERIZED SIMULATION
CONTRAST MEDIA
EXPERIMENT RESULTS
LASER RADIATION
LIGHT SCATTERING
NANOPARTICLES
PHANTOMS
POROUS MATERIALS
SILICON
TOMOGRAPHY
WATER
WAVELENGTHS