Prenatal dichlorodiphenyldichloroethylene (DDE) exposure and child growth during the first year of life
- Department of Preventive Medicine, Mount Sinai School of Medicine, International Training and Research in Environmental and Occupational Health Program, 17 E 102nd Street, CAM Building, 3 West, One Gustave L. Levy Place, Box 1057, New York, NY 10029 (United States)
- National Institute of Public Health, Av. Universidad 655, Col. Sta Maria Ahuacatitlan, C.P. 62100 Cuernavaca, Morelos (Mexico)
Background: Due to its long-term persistence in the environment and its ability to cross the placental barrier, prenatal p,p Prime -dichlorodiphenyldichloroethene (DDE) exposure continues to be a public health concern. This study aimed to evaluate the association between prenatal DDE exposure and child growth, at birth and during the first year of life. Methods: 253 pregnant women were recruited between January 2001 and June 2005 in a prospective cohort in Morelos, Mexico. Serum levels of DDE were measured during each trimester of pregnancy by gas chromatography with an electron capture detector. Using the generalized mixed-effects models, the association between DDE and child growth parameters (weight-for-age, length-for-age, weight-for-length, BMI-for-age and head circumference-for-age Z-scores) from birth to 1 year of age was assessed. Maternal dietary intake was considered as covariable among others. Results: DDE levels were 6.3{+-}2.8 ng/mL (first trimester), 6.6{+-}2.9 ng/mL (second trimester), and 7.6{+-}2.9 ng/mL (third trimester). After adjusting for potential confounder variables, no significant associations were observed with prenatal DDE exposure and each of the selected parameters. Conclusions: Our results show no evidence of an association between prenatal DDE exposure and child growth during the first year of life.
- OSTI ID:
- 22156258
- Journal Information:
- Environmental Research, Vol. 113; Other Information: Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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