Biomolecular Emission by Swift Heavy Ion Bombardment

Journal Article · Fri Jan 07 00:00:00 EST 2011 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3548357· OSTI ID:21510099

Wakamatsu, Yoshinobu; Yamada, Hideaki ^[1]; Ninomiya, Satoshi; Matsuo, Jiro ^[2]; Jones, Brian N; Webb, Roger ^[3]; Seki, Toshio ^[1]; Aoki, Takaaki ^[4]

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1. Department of Nuclear Engineering, Kyoto University, Sakyo, Kyoto, 606-8501 (Japan)
2. Quantum Science and Engineering Center, Kyoto University. Uji, Kyoto 611-0011 (Japan)
3. Ion Beam Centre, University of Surrey, Surrey GU2 7XH (United Kingdom)
4. Department of Electronic Science and Engineering, Kyoto University, Nishikyo Kyoto 615-8510 (Japan)

Secondary Ion Mass spectrometry (SIMS) has been generally used in the field of material sciences. In recent years, it has also been applied for molecular imaging of biological samples. Nevertheless, molecular ions derived from the large molecules (more than 1 kDa) were detected with very low sensitivity. Plasma desorption mass spectrometry (PDMS) is known as mass spectrometry for large organic molecule. In PDMS, fission fragments bombard samples and the impact induces molecular ionization by electronic excitation. Large organic molecules are detected by using swift heavy ions in SIMS. In this work, 6 MeV Cu{sup 4+} we irradiated angiotensin II, a class of peptides. The intact molecular ions generated by swift heavy ion irradiation were analyzed by time-of-flight (TOF) measurement. The yields are compared with some other probe ions, bismuth or flurane. Swift heavy ion bombardment ionized large organic molecules more effectively than other probes. Therefore, high energy ion can be applied in high resolution molecular imaging.

• OSTI ID: 21510099
• Journal Information: AIP Conference Proceedings, Vol. 1321, Issue 1; Conference: IIT 2010: 18. international conference on ion implantation technology, Kyoto (Japan), 6-11 Jun 2010; Other Information: DOI: 10.1063/1.3548357; (c) 2010 American Institute of Physics; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

74 ATOMIC AND MOLECULAR PHYSICS
ANGIOTENSIN
COPPER IONS
DESORPTION
EMISSION
EXCITATION
EXCITED STATES
FISSION FRAGMENTS
HEAVY IONS
IMPURITIES
ION MICROPROBE ANALYSIS
IONIZATION
MASS SPECTROSCOPY
MEV RANGE 01-10
MOLECULAR IONS
MULTICHARGED IONS
PEPTIDES
PLASMA
RESOLUTION
SENSITIVITY
TIME-OF-FLIGHT METHOD
CARDIOVASCULAR AGENTS
CHARGED PARTICLES
CHEMICAL ANALYSIS
DRUGS
ENERGY LEVELS
ENERGY RANGE
ENERGY-LEVEL TRANSITIONS
GLOBULINS
IONS
MEV RANGE
MICROANALYSIS
NONDESTRUCTIVE ANALYSIS
NUCLEAR FRAGMENTS
ORGANIC COMPOUNDS
PROTEINS
SORPTION
SPECTROSCOPY
VASOCONSTRICTORS