Testing the equivalencies of concentration response distributions in aquatic toxicology studies
- Miami Univ., Oxford, OH (United States)
The purpose of this study was to describe statistical procedures to test the equivalencies of concentration response distributions in aquatic toxicology studies. Commonly the only endpoint compared in acute toxicity testing is the concentration associated with the mean adverse response (LC50) between two test populations. However, other endpoint comparisons may be more meaningful in a risk assessment context (eg., LC10). In addition, assessing the equivalency of slopes between concentration response distributions may lend insight into the characteristics of the overall population mortality response to a toxicant. A regression model that allowed for the examination of equivalence of slopes and intercepts of the responses between populations was developed using probit and logistic regression. Test statistics were derived from comparing nested regression models. This procedure was used to test the equivalency of the fluoranthene concentration versus acute mortality response relationships between two populations of fish, one of which had experienced long-term low-level fluoranthene exposure and putatively had developed genetically-based tolerance to fluoranthene toxicity. Results from this study indicated that this procedure can be used to acquire hazard assessment information from acute toxicity studies that cannot be obtained utilizing standard analysis techniques.
- OSTI ID:
- 212090
- Report Number(s):
- CONF-9511137-; ISBN 1-880611-03-1; TRN: IM9617%%406
- Resource Relation:
- Conference: 2. Society of Environmental Toxicology and Chemistry (SETAC) world conference, Vancouver (Canada), 5-9 Nov 1995; Other Information: PBD: 1995; Related Information: Is Part Of Second SETAC world congress (16. annual meeting): Abstract book. Global environmental protection: Science, politics, and common sense; PB: 378 p.
- Country of Publication:
- United States
- Language:
- English
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