A simple geometric algorithm to predict optimal starting gantry angles using equiangular-spaced beams for intensity modulated radiation therapy of prostate cancer
- Department of Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba, R3T 2N2 (Canada) and Division of Medical Physics, CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba R3E 0V9 (Canada)
A fast, geometric beam angle optimization (BAO) algorithm for clinical intensity-modulated radiation therapy (IMRT) was implemented on ten localized prostate cancer patients on the Radiation Therapy Oncology Group (RTOG) 0126 protocol. The BAO algorithm computed the beam intersection volume (BIV) within the rectum and bladder using five and seven equiangular-spaced beams as a function of starting gantry angle for comparison to the V 75 Gy and V 70 Gy. A mathematical theory was presented to explain the correlation of BIV with dose and dose-volume metrics. The class solution 'W' pattern in the rectal V 75 Gy and V 70 Gy as a function of starting gantry angle using five equiangular-spaced beams (with two separate minima centered near 20 deg. and 50 deg. ) was reproduced by the 5 BIV within the rectum. A strong correlation was found between the rectal 5 BIV and the rectal V 75 Gy and V 70 Gy as a function of starting gantry angle. The BAO algorithm predicted the location of the two dosimetric minima in rectal V 75 Gy and V 70 Gy (optimal starting gantry angles) to within 5 deg. . It was demonstrated that the BIV geometric variations for seven equiangular-spaced beams were too small to translate into a strong dosimetric effect in the rectal V 75 Gy and V 70 Gy. The relatively flat distribution with starting gantry angle of the bladder V 75 Gy and V 70 Gy was reproduced by the bladder five and seven BIV for each patient. A geometric BAO method based on BIV has the advantage over dosimetric BAO methods of simplicity and rapid computation time. This algorithm can be used as a standalone optimization method or act as a rapid calculation filter to reduce the search space for a dosimetric BAO method. Given the clinically infeasible computation times of many dosimetric beam orientation optimization algorithms, this robust geometric BIV algorithm has the potential to facilitate beam angle selection for prostate IMRT in clinical practice.
- OSTI ID:
- 21032811
- Journal Information:
- Medical Physics, Vol. 34, Issue 10; Other Information: DOI: 10.1118/1.2775685; (c) 2007 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-2405
- Country of Publication:
- United States
- Language:
- English
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