Dose-volume histogram representation of patient dose distribution in three-dimensional internal dosimetry

Journal Article · Sun May 01 00:00:00 EDT 1994 · Journal of Nuclear Medicine

OSTI ID:197992

Kolbert, K S; Sgouros, G; Scott, A M ^[1]

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1. Memorial Sloan-Kettering Cancer Center, New York, NY (United States); and others

To understand tumor response and normal organ toxicity following internal emitter therapy a succinct yet adequate representation of the spatial dose distribution within the target is necessary. Using 3D-ID, a software package that implements a patient-specific, three-dimensional approach to dosimetry, we obtain the mean and a dose-volume histogram of the spatial dose distribution to a target volume. Registered CT/MR and SPECT/PET images (generated using Pelizzari/Chen registration software) are used to define the radioactivity distribution relative to patient anatomy. Target contours are drawn on side-by-side enlarged SPECT/PET and CT/MR image slices that are selected from a scrollable image display. Contours drawn in one modality simultaneously appear in the other. The user may switch between modalities by positioning the cursor in the appropriate window. This provides for the simultaneous use of both imaging modalities to define tumor (e.g. using SPECT) and normal organ (using CT/MR) contours. The dose to all voxels within the target volume is obtained by convolving the activity distribution with a point kernel table of absorbed dose versus distance. Patient-specific S-factors may be calculated by defining source organ contours and assigning unit activity to all voxels within each source. The {open_quotes}dose{close_quotes} to a given target is thus the patient-specific S-factor In the first patient examined using 3D-ID, approximately 16% of the tumor volume received a dose that was 25% less than the mean dose. The liver to spleen S-factor for this patient differed from the standard man value by approximately 48%; when the value was adjusted for the patient`s (enlarged) spleen volume the difference was approximately 21%. Dose histograms and patient-specific organ and tumor S-factors generated using 3D-ID may provide useful information in understanding tumor response and organ toxicity in radioimmunotherapy.

• OSTI ID: 197992
• Report Number(s): CONF-940605-; ISSN 0161-5505; TRN: 95:007029-0132
• Journal Information: Journal of Nuclear Medicine, Vol. 35, Issue Suppl.5; Conference: 41. annual meeting of the Society of Nuclear Medicine, Orlando, FL (United States), 5-8 Jun 1994; Other Information: PBD: May 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
99 MATHEMATICS
COMPUTERS
INFORMATION SCIENCE
MANAGEMENT
LAW
MISCELLANEOUS
RADIOIMMUNOTHERAPY
DOSIMETRY
RADIATION DOSES
SPATIAL DISTRIBUTION
IMAGES
LIVER
SPLEEN
TOXICITY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
POSITRON COMPUTED TOMOGRAPHY
COMPUTER CODES