Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)

Dampalla, Chamandi S.; Miller, Matthew J.; Kim, Yunjeong; Zabiegala, Alexandria; Nguyen, Harry Nhat; Madden, Trent K.; Thurman, Hayden A.; Machen, Alexandra J.; Cooper, Anne; Liu, Lijun; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C.

doi:10.1016/j.ejmech.2023.115376

Title: Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)

Journal Article · Thu Jun 01 00:00:00 EDT 2023 · European Journal of Medicinal Chemistry

DOI:https://doi.org/10.1016/j.ejmech.2023.115376· OSTI ID:1970422

; Miller, Matthew J.; Kim, Yunjeong; Zabiegala, Alexandria; Nguyen, Harry Nhat; Madden, Trent K.; Thurman, Hayden A.; Machen, Alexandra J.; Cooper, Anne; Liu, Lijun; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C.

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Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: KP1605010; 10RR024664; AC02-06CH11357; SC0012704; S10OD030394

OSTI ID:: 1970422

Journal Information:: European Journal of Medicinal Chemistry, Journal Name: European Journal of Medicinal Chemistry Vol. 254 Journal Issue: C; ISSN 0223-5234

Publisher:: ElsevierCopyright Statement

Country of Publication:: France

Language:: English

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