Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care

Zhang, Jinyuan; Kim, Kyunghun; Kim, Ho Joong; Meyer, Dawn; Park, Woohyun; Lee, Seul Ah; Dai, Yumin; Kim, Bongjoong; Moon, Haesoo; Shah, Jay V.; Harris, Keely E.; Collar, Brett; Liu, Kangying; Irazoqui, Pedro; Lee, Hyowon; Park, Shin Ae; Kollbaum, Pete S.; Boudouris, Bryan W.; Lee, Chi Hwan

doi:10.1038/s41467-022-33254-4

Title: Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care

Journal Article · Tue Sep 20 00:00:00 EDT 2022 · Nature Communications

DOI:https://doi.org/10.1038/s41467-022-33254-4· OSTI ID:1903256

Zhang, Jinyuan ^[1]; Kim, Kyunghun ^[1]; Kim, Ho Joong ^[1]; Meyer, Dawn ^[2];

^[1]; Lee, Seul Ah ^[1]; Dai, Yumin ^[1]; Kim, Bongjoong ^[3]; Moon, Haesoo ^[1]; Shah, Jay V. ^[1]; Harris, Keely E. ^[1]; Collar, Brett ^[4]; Liu, Kangying ^[1]; Irazoqui, Pedro ^[4];

^[1];

^[5];

^[1];

^[5]

Purdue Univ., West Lafayette, IN (United States)
Indiana Univ., Bloomington, IN (United States)
Purdue Univ., West Lafayette, IN (United States); Hongik Univ., Seoul (Korea, Republic of)
Johns Hopkins Univ., Baltimore, MD (United States)
Purdue Univ., West Lafayette, IN (United States); Indiana Univ., Bloomington, IN (United States)

Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand challenge in glaucoma care. Here we introduce a class of smart soft contact lenses, enabling the continuous 24-hour monitoring of intraocular pressure, even during sleep. Uniquely, the smart soft contact lenses are built upon various commercial brands of soft contact lenses without altering their intrinsic properties such as lens power, biocompatibility, softness, transparency, wettability, oxygen transmissibility, and overnight wearability. We show that the smart soft contact lenses can seamlessly fit across different corneal curvatures and thicknesses in human eyes and therefore accurately measure absolute intraocular pressure under ambulatory conditions. We perform a comprehensive set of in vivo evaluations in rabbit, dog, and human eyes from normal to hypertension to confirm the superior measurement accuracy, within-subject repeatability, and user comfort of the smart soft contact lenses beyond current wearable ocular tonometers. We envision that the smart soft contact lenses will be effective in glaucoma care.

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Research Organization:: Purdue Univ., West Lafayette, IN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division

Grant/Contract Number:: SC0021967

OSTI ID:: 1903256

Journal Information:: Nature Communications, Vol. 13, Issue 1; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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