The murine homeobox genes Nkx2.3 and Nkx2.6 are located on chromosomes 19 and 14, respectively
- National Cancer Institute, Frederick, MD (United States)
- Walter and Eliza Hall Institute of Medical Research, Victoria (Australia)
The mouse chromosomal locations of two murine homeobox genes, Nkx2.3 and Nkx2.6, were determined by interspecific backcross analysis using progeny derived from matings of [(C57BL/6J x Mus spretus) F1 x C57BL/6J] mice. This interspecific backcross mapping panel has been typed for over 1400 loci that are well distributed among all the autosomes as well as the X chromosomes. The mapping data indicated that Nkx2.3 is located in the distal region of mouse chromosome 19. This distal region of mouse chromosome 19 shares homology with human chromosome 10q, suggesting that the human homologue of Nkx2.3 will map to this region of chromosome 10. The mapping data indicated that the Nkx2.6 gene is located in the middle region of chromosome 14. This region of mouse chromosome 14 shares homology with human chromosome 8p, suggesting that the human homologue of Nkx2.6 will map to this region of human chromosome 8.
- OSTI ID:
- 186049
- Journal Information:
- Genomics, Vol. 22, Issue 3; Other Information: PBD: Aug 1994
- Country of Publication:
- United States
- Language:
- English
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