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Title: Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition

Journal Article · · EMBO J.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; FOREIGN; National Institutes of Health (NIH)
OSTI ID:
1845466
Journal Information:
EMBO J., Vol. 37, Issue (1)
Country of Publication:
United States
Language:
ENGLISH

References (37)

PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Molecular Basis for Target RNA Recognition and Cleavage by Human RISC journal July 2007
Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA journal January 2001
A Dynamic Search Process Underlies MicroRNA Targeting journal July 2015
Features and development of Coot journal March 2010
The Making of a Slicer: Activation of Human Argonaute-1 journal June 2013
Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates journal December 2012
Most mammalian mRNAs are conserved targets of microRNAs journal October 2008
Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs journal September 2011
Recent progress toward the use of circulating microRNAs as clinical biomarkers journal September 2016
Kinetic analysis of the RNAi enzyme complex journal May 2004
Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs journal July 2015
XDS journal January 2010
Why Argonaute is needed to make microRNA target search fast and reliable journal May 2017
Identification of Novel Genes Coding for Small Expressed RNAs journal October 2001
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans journal October 2001
An Extensive Class of Small RNAs in Caenorhabditis elegans journal October 2001
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets journal January 2005
The microcosmos of cancer journal February 2012
Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein journal March 2005
Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA journal October 2016
Structure of yeast Argonaute with guide RNA journal May 2012
Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity journal June 2013
Carbodiimide-mediated cross-linking of RNA to nylon membranes improves the detection of siRNA, miRNA and piRNA by northern blot journal March 2007
Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex journal March 2005
Enhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain Protein journal January 2009
Hydration of short DNA, RNA and 2'-OMe oligonucleotides determined by osmotic stressing journal January 2004
Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides journal July 2015
The Crystal Structure of Human Argonaute2 journal April 2012
Structural basis for microRNA targeting journal October 2014
Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets journal September 2015
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex journal December 2008
Structure of the guide-strand-containing argonaute silencing complex journal August 2008
Argonaute Divides Its RNA Guide into Domains with Distinct Functions and RNA-Binding Properties journal November 2012
Overview of the CCP 4 suite and current developments journal March 2011
A double-filter method for nitrocellulose-filter binding: application to protein-nucleic acid interactions. journal June 1993
MicroRNAs in heart failure: Non-coding regulators of metabolic function journal December 2016