Using Lactobacilli to Fight Escherichia coli and Staphylococcus aureus Biofilms on Urinary Tract Devices

Carvalho, Fábio M.; Mergulhão, Filipe J. M.; Gomes, Luciana C.

doi:10.3390/antibiotics10121525

Title: Using Lactobacilli to Fight Escherichia coli and Staphylococcus aureus Biofilms on Urinary Tract Devices

Journal Article · Tue Dec 14 00:00:00 EST 2021 · Antibiotics

DOI:https://doi.org/10.3390/antibiotics10121525· OSTI ID:1835627

Carvalho, Fábio M.;

;

The low efficacy of conventional treatments and the interest in finding natural-based approaches to counteract biofilm development on urinary tract devices have promoted the research on probiotics. This work evaluated the ability of two probiotic strains, Lactobacillus plantarum and Lactobacillus rhamnosus, in displacing pre-formed biofilms of Escherichia coli and Staphylococcus aureus from medical-grade silicone. Single-species biofilms of 24 h were placed in contact with each probiotic suspension for 6 h and 24 h, and the reductions in biofilm cell culturability and total biomass were monitored by counting colony-forming units and crystal violet assay, respectively. Both probiotics significantly reduced the culturability of E. coli and S. aureus biofilms, mainly after 24 h of exposure, with reduction percentages of 70% and 77% for L. plantarum and 76% and 63% for L. rhamnosus, respectively. Additionally, the amount of E. coli biofilm determined by CV staining was maintained approximately constant after 6 h of probiotic contact and significantly reduced up to 67% after 24 h. For S. aureus, only L. rhamnosus caused a significant effect on biofilm amount after 6 h of treatment. Hence, this study demonstrated the potential of lactobacilli to control the development of pre-established uropathogenic biofilms.

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Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Transportation Office. Fuel Cell Technologies Office

Grant/Contract Number:: Project PTDC/CTMCOM/4844/2020; Scientific Employment Stimulus-Individual Call-[CEEC-IND/01700/2017]

OSTI ID:: 1835627

Journal Information:: Antibiotics, Journal Name: Antibiotics Vol. 10 Journal Issue: 12; ISSN 2079-6382

Publisher:: MDPICopyright Statement

Country of Publication:: Switzerland

Language:: English

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