Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite

Lam, Tu-Ngoc; Trinh, Minh-Giam; Huang, Chih-Chieh; Kung, Pei-Ching; Huang, Wei-Chin; Chang, Wei; Amalia, Lia; Chin, Hsu-Hsuan; Tsou, Nien-Ti; Shih, Shao-Ju; Chen, San-Yuan; Wang, Chun-Chieh; Tsai, Pei-I; Wu, Meng-Huang; Huang, E-Wen

doi:10.3390/ijms21207438

Title: Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite

Journal Article · Fri Oct 09 00:00:00 EDT 2020 · International Journal of Molecular Sciences (Online)

DOI:https://doi.org/10.3390/ijms21207438· OSTI ID:1817109

Lam, Tu-Ngoc ^[1]; Trinh, Minh-Giam ^[2]; Huang, Chih-Chieh ^[3];

^[3]; Huang, Wei-Chin ^[4]; Chang, Wei ^[3]; Amalia, Lia ^[3]; Chin, Hsu-Hsuan ^[3];

^[3];

^[5]; Chen, San-Yuan ^[3]; Wang, Chun-Chieh ^[6];

^[7];

^[8];

^[3]

National Chiao Tung Univ., Hsinchu (Taiwan). Dept. of Materials Science and Engineering; Can Tho Univ., Can Tho City (Vietnam). College of Education. Dept. of Physics
Taipei Medical Univ., Taipei (Taiwan). College of Medicine. International Ph.D. Program in Medicine; Pham Ngoc Thach Medical Univ., Ho Chi Minh City (Vietnam). College of Medicine. Dept. of Trauma-Orthopaedics
National Chiao Tung Univ., Hsinchu (Taiwan). Dept. of Materials Science and Engineering
Industrial Technology Research Inst., Hsinchu (Taiwan). Laser and Additive Manufacturing Technology Center
National Taiwan Univ. of Science and Technology, Taipei (Taiwan). Dept. of Materials Science and Engineering
National Synchrotron Radiation Research Center, Hsinchu (Taiwan)
Industrial Technology Research Inst., Hsinchu (Taiwan)
Taipei Medical Univ. (Taiwan). College of Medicine. School of Medicine. Dept. of Orthopaedics; Taipei Medical Univ. Hospital, Taipei (Taiwan). Dept. of Orthopedics

In this study, we optimized the geometry and composition of additive-manufactured pedicle screws. Metal powders of titanium-aluminum-vanadium (Ti-6Al-4V) were mixed with reactive glass-ceramic biomaterials of bioactive glass (BG) powders. To optimize the geometry of pedicle screws, we applied a novel numerical approach to proposing the optimal shape of the healing chamber to promote biological healing. We examined the geometry and composition effects of pedicle screw implants on the interfacial autologous bone attachment and bone graft incorporation through in vivo studies. The addition of an optimal amount of BG to Ti-6Al-4V leads to a lower elastic modulus of the ceramic-metal composite material, effectively reducing the stress-shielding effects. Pedicle screw implants with optimal shape design and made of the composite material of Ti-6Al-4V doped with BG fabricated through additive manufacturing exhibit greater osseointegration and a more rapid bone volume fraction during the fracture healing process 120 days after implantation, per in vivo studies.

View Accepted Manuscript (DOE)

Cite

Export

Save

Sponsoring Organization:: USDOE Office of Science (SC); Ministry of Science and Technology (MOST)

Grant/Contract Number:: AC05-00OR22725; MOST 109-2634-F-009-029; MOST-108-2739-M-213-001

OSTI ID:: 1817109

Journal Information:: International Journal of Molecular Sciences (Online), Vol. 21, Issue 20; ISSN 1422-0067

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

References (51)

Solidification microstructure simulation of Ti-6Al-4V in metal additive manufacturing: A review Li, Jinghao; Zhou, Xianglin; Brochu, Mathieu Additive Manufacturing, Vol. 31 https://doi.org/10.1016/j.addma.2019.100989	journal	January 2020
Binary titanium alloys as dental implant materials—a review Liu, Xiaotian; Chen, Shuyang; Tsoi, James K. H. Regenerative Biomaterials, Vol. 4, Issue 5 https://doi.org/10.1093/rb/rbx027	journal	September 2017
Novel Bioactive Functionally Graded Coatings on Ti6Al4V Gomez-Vega, J. M.; Saiz, E.; Tomsia, A. P. Advanced Materials, Vol. 12, Issue 12 https://doi.org/10.1002/1521-4095(200006)12:12<894::AID-ADMA894>3.0.CO;2-4	journal	June 2000
Pedicle screw fixation in spinal disorders: A European view Boos, N.; Webb, J. K. European Spine Journal, Vol. 6, Issue 1 https://doi.org/10.1007/BF01676569	journal	January 1997
The Effect of Mesoporous Bioactive Glass Nanoparticles/Graphene Oxide Composites on the Differentiation and Mineralization of Human Dental Pulp Stem Cells Ahn, Jae Hwa; Kim, In-Ryoung; Kim, Yeon Nanomaterials, Vol. 10, Issue 4 https://doi.org/10.3390/nano10040620	journal	March 2020
The Calculation of X‐Ray Mass Absorption Coefficients Victoreen, John A. Journal of Applied Physics, Vol. 20, Issue 12 https://doi.org/10.1063/1.1698286	journal	December 1949
A Method of Spinal Fusion Boucher, H. H. The Journal of Bone and Joint Surgery. British volume, Vol. 41-B, Issue 2 https://doi.org/10.1302/0301-620X.41B2.248	journal	May 1959
3D printed Ti6Al4V implant surface promotes bone maturation and retains a higher density of less aged osteocytes at the bone-implant interface Shah, Furqan A.; Snis, Anders; Matic, Aleksandar Acta Biomaterialia, Vol. 30 https://doi.org/10.1016/j.actbio.2015.11.013	journal	January 2016
Preparation and in Vitro Bioactivity of Micron-sized Bioactive Glass Particles Using Spray Drying Method Chou, Yu-Jen; Hsiao, Chih-Wei; Tsou, Nien-Ti Applied Sciences, Vol. 9, Issue 1 https://doi.org/10.3390/app9010019	journal	December 2018
Functional Bioglass—Biopolymer Double Nanostructure for Natural Antimicrobial Drug Extracts Delivery Negut, Irina; Floroian, Laura; Ristoscu, Carmen Nanomaterials, Vol. 10, Issue 2 https://doi.org/10.3390/nano10020385	journal	February 2020
Case study of Ti6Al4V pedicle screw failures due to geometric and microstructural aspects Griza, Sandro; de Andrade, Carlos Eduardo C.; Batista, Wilton W. Engineering Failure Analysis, Vol. 25 https://doi.org/10.1016/j.engfailanal.2012.05.009	journal	October 2012
A mechano-regulation model for tissue differentiation during fracture healing: analysis of gap size and loading Lacroix, D.; Prendergast, P. J. Journal of Biomechanics, Vol. 35, Issue 9 https://doi.org/10.1016/S0021-9290(02)00086-6	journal	September 2002
Preliminary observations of bone ingrowth into porous materials Robertson, Diane M.; St. Pierre, Leon; Chahal, Ramlal Journal of Biomedical Materials Research, Vol. 10, Issue 3 https://doi.org/10.1002/jbm.820100304	journal	May 1976
Evaluation of osseous integration of titanium orthopedic screws with novel SLA treatment in porcine model Lin, Tzu-Hsiang; Hu, Hsin-Tai; Wang, Hsueh-Chun PLOS ONE, Vol. 12, Issue 11 https://doi.org/10.1371/journal.pone.0188364	journal	November 2017
As-fabricated surface morphologies of Ti-6Al-4V samples fabricated by different laser processing parameters in selective laser melting Pal, Snehashis; Lojen, Gorazd; Hudak, Radovan Additive Manufacturing, Vol. 33 https://doi.org/10.1016/j.addma.2020.101147	journal	May 2020
The effect of thread pattern upon implant osseointegration Abuhussein, Heba; Pagni, Giorgio; Rebaudi, Alberto Clinical Oral Implants Research, Vol. 21, Issue 2 https://doi.org/10.1111/j.1600-0501.2009.01800.x	journal	February 2010
Hardening steels by the generation of transient phase using additive manufacturing Huang, E-Wen; Lee, Soo Yeol; Jain, Jayant Intermetallics, Vol. 109 https://doi.org/10.1016/j.intermet.2019.03.004	journal	June 2019
Evolution and Function of Dinosaur Teeth at Ultramicrostructural Level Revealed Using Synchrotron Transmission X-ray Microscopy Wang, Chun-Chieh; Song, Yen-Fang; Song, Sheng-Rong Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep15202	journal	October 2015
Pedicle Screw Fixation Study in Immature Porcine Spines to Improve Pullout Resistance during Animal Testing Le Cann, Sophie; Cachon, Thibaut; Viguier, Eric PLOS ONE, Vol. 10, Issue 10 https://doi.org/10.1371/journal.pone.0127463	journal	October 2015
Transpedicular screw-rod fixation of the lumbar spine: operative technique and outcome in 104 cases Dickman, Curtis A.; Fessler, Richard G.; MacMillan, Michael Journal of Neurosurgery, Vol. 77, Issue 6 https://doi.org/10.3171/jns.1992.77.6.0860	journal	December 1992
Pull out strength calculator for pedicle screws using a surrogate ensemble approach Varghese, Vicky; Ramu, Palaniappan; Krishnan, Venkatesh Computer Methods and Programs in Biomedicine, Vol. 137 https://doi.org/10.1016/j.cmpb.2016.08.023	journal	December 2016
Osseointegration improves bone–implant interface of pedicle screws in the growing spine: a biomechanical and histological study using an in vivo immature porcine model Shiba, Kanako; Taneichi, Hiroshi; Namikawa, Takashi European Spine Journal, Vol. 26, Issue 11 https://doi.org/10.1007/s00586-017-5062-2	journal	April 2017
Micro-CT in small animal and specimen imaging Holdsworth, David W.; Thornton, Michael M. Trends in Biotechnology, Vol. 20, Issue 8 https://doi.org/10.1016/S0167-7799(02)02004-8	journal	August 2002
Bioactive glasses for in situ tissue regeneration Hench, Larry L.; Xynos, Ionnis D.; Polak, Julia M. Journal of Biomaterials Science, Polymer Edition, Vol. 15, Issue 4 https://doi.org/10.1163/156856204323005352	journal	January 2004
Plastic Deformation of a Nano-Precipitate Strengthened Ni-Base Alloy Investigated by Complementary In Situ Neutron Diffraction Measurements and Molecular-Dynamics Simulations Huang, E-Wen; Csiszár, Gabor; Lo, Yu-Chieh Advanced Engineering Materials, Vol. 14, Issue 10 https://doi.org/10.1002/adem.201200057	journal	July 2012
Das Gesetz der Transformation der Knochen Wolff, Julius DMW - Deutsche Medizinische Wochenschrift, Vol. 19, Issue 47 https://doi.org/10.1055/s-0028-1144106	journal	November 1893
Biomechanical model to simulate tissue differentiation and bone regeneration: Application to fracture healing Lacroix, D.; Prendergast, P. J.; Li, G. Medical & Biological Engineering & Computing, Vol. 40, Issue 1 https://doi.org/10.1007/BF02347690	journal	January 2002
Additive manufacturing of Ti6Al4V alloy: A review Liu, Shunyu; Shin, Yung C. Materials & Design, Vol. 164 https://doi.org/10.1016/j.matdes.2018.107552	journal	February 2019
Well-ordered mesoporous bioactive glasses (MBG): A promising bioactive drug delivery system Xia, Wei; Chang, Jiang Journal of Controlled Release, Vol. 110, Issue 3 https://doi.org/10.1016/j.jconrel.2005.11.002	journal	February 2006
Bonding mechanisms at the interface of ceramic prosthetic materials Hench, L. L.; Splinter, R. J.; Allen, W. C. Journal of Biomedical Materials Research, Vol. 5, Issue 6 https://doi.org/10.1002/jbm.820050611	journal	November 1971
Hydroxyapatite coating improves fixation of pedicle screws: A CLINICAL STUDY Sandén, B.; Olerud, C.; Petrén-Mallmin, M. The Journal of Bone and Joint Surgery. British volume, Vol. 84-B, Issue 3 https://doi.org/10.1302/0301-620X.84B3.0840387	journal	April 2002
Designs and Techniques That Improve the Pullout Strength of Pedicle Screws in Osteoporotic Vertebrae: Current Status Shea, Thomas M.; Laun, Jake; Gonzalez-Blohm, Sabrina A. BioMed Research International, Vol. 2014 https://doi.org/10.1155/2014/748393	journal	January 2014
Micro-Layer and Lattice Structure Effects on Impedance of Titanium Oxide Phthalocyanine Lam, Tu-Ngoc; Huang, Wei-Jie; Wang, Chun-Chieh Advanced Engineering Materials, Vol. 20, Issue 7 https://doi.org/10.1002/adem.201701140	journal	April 2018
Microstructure and mechanical behavior of Ti–6Al–4V produced by rapid-layer manufacturing, for biomedical applications Murr, L. E.; Quinones, S. A.; Gaytan, S. M. Journal of the Mechanical Behavior of Biomedical Materials, Vol. 2, Issue 1 https://doi.org/10.1016/j.jmbbm.2008.05.004	journal	January 2009
Porous Ti6Al4V Scaffold Directly Fabricated by Sintering: Preparation and In Vivo Experiment Zhang, Xuesong; Zheng, Guoquan; Wang, Jiaqi Journal of Nanomaterials, Vol. 2013 https://doi.org/10.1155/2013/205076	journal	January 2013
Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants Tsai, Pei-I.; Lam, Tu-Ngoc; Wu, Meng-Huang Materials Chemistry and Physics, Vol. 230 https://doi.org/10.1016/j.matchemphys.2019.03.047	journal	May 2019
Biomaterials in Spinal Implants: A Review Warburton, Andrew; Girdler, Steven J.; Mikhail, Christopher M. Neurospine, Vol. 17, Issue 1 https://doi.org/10.14245/ns.1938296.148	journal	March 2020
Effect of various factors on pull out strength of pedicle screw in normal and osteoporotic cancellous bone models Varghese, Vicky; Saravana Kumar, Gurunathan; Krishnan, Venkatesh Medical Engineering & Physics, Vol. 40 https://doi.org/10.1016/j.medengphy.2016.11.012	journal	February 2017
Bone formation during forelimb regeneration: A microtomography (microCT) analysis Stock, Stuart R.; Blackburn, David; Gradassi, Michael Developmental Dynamics, Vol. 226, Issue 2 https://doi.org/10.1002/dvdy.10241	journal	February 2003
Numerical Method for the Design of Healing Chamber in Additive-Manufactured Dental Implants Lee, Hsiao-Chien; Tsai, Pei-I; Huang, Chih-Chieh BioMed Research International, Vol. 2017 https://doi.org/10.1155/2017/1970680	journal	January 2017
Deformations of Ti-6Al-4V additive-manufacturing-induced isotropic and anisotropic columnar structures: Insitu measurements and underlying mechanisms Tseng, Jo-Chi; Huang, Wei-Chin; Chang, Wei Additive Manufacturing, Vol. 35 https://doi.org/10.1016/j.addma.2020.101322	journal	October 2020
Plastic anisotropy and deformation-induced phase transformation of additive manufactured stainless steel Chae, Hobyung; Huang, E-Wen; Jain, Jayant Materials Science and Engineering: A, Vol. 762 https://doi.org/10.1016/j.msea.2019.138065	journal	August 2019
New Developments of Ti-Based Alloys for Biomedical Applications Li, Yuhua; Yang, Chao; Zhao, Haidong Materials, Vol. 7, Issue 3 https://doi.org/10.3390/ma7031709	journal	March 2014
Evaluation of Titanium-Coated Pedicle Screws: In Vivo Porcine Lumbar Spine Model Kim, Do-Yeon; Kim, Jung-Ryul; Jang, Kyu Yun World Neurosurgery, Vol. 91 https://doi.org/10.1016/j.wneu.2016.03.089	journal	July 2016
Factors Affecting the Pullout Strength of Cancellous Bone Screws Chapman, J. R.; Harrington, R. M.; Lee, K. M. Journal of Biomechanical Engineering, Vol. 118, Issue 3 https://doi.org/10.1115/1.2796022	journal	August 1996
Early Bone Healing around Different Implant Bulk Designs and Surgical Techniques: A Study in Dogs Coelho, Paulo G.; Suzuki, Marcelo; Guimaraes, Marcia V. M. Clinical Implant Dentistry and Related Research https://doi.org/10.1111/j.1708-8208.2009.00153.x	journal	June 2009
Sol–gel based fabrication and characterization of new bioactive glass–ceramic composites for dental applications Chatzistavrou, Xanthippi; Tsigkou, Olga; Amin, Harsh D. Journal of the European Ceramic Society, Vol. 32, Issue 12 https://doi.org/10.1016/j.jeurceramsoc.2012.04.037	journal	September 2012
Titanium-alloy enhances bone-pedicle screw fixation: mechanical and histomorphometrical results of titanium-alloy versus stainless steel Christensen, F. B.; Dalstra, M.; Sejling, F. European Spine Journal, Vol. 9, Issue 2 https://doi.org/10.1007/s005860050218	journal	April 2000
Characterization of eight different tetracyclines: advances in fluorescence bone labeling: Characterization of different tetracyclines Pautke, Christoph; Vogt, Stephan; Kreutzer, Kilian Journal of Anatomy, Vol. 217, Issue 1 https://doi.org/10.1111/j.1469-7580.2010.01237.x	journal	April 2010
A Three-Dimensional Finite Element Study on the Biomechanical Simulation of Various Structured Dental Implants and Their Surrounding Bone Tissues Zhang, Gong; Yuan, Hai; Chen, Xianshuai International Journal of Dentistry, Vol. 2016 https://doi.org/10.1155/2016/4867402	journal	January 2016
Bioactive pedicle screws prepared by chemical and heat treatments improved biocompatibility and bone-bonding ability in canine lumbar spines Akeda, Koji; Yamaguchi, Seiji; Matsushita, Tomiharu PLOS ONE, Vol. 13, Issue 5 https://doi.org/10.1371/journal.pone.0196766	journal	May 2018

Similar Records

SU-E-T-609: Perturbation Effects of Pedicle Screws On Radiotherapy Dose Distributions

Journal Article · Mon Jun 15 00:00:00 EDT 2015 · Medical Physics · OSTI ID:1817109

Bar-Deroma, R; Borzov, E; Nevelsky, A

Structural characterization of the metal/glass interface in bioactive glass coatings on Ti-6Al-4V

Journal Article · Wed Dec 01 00:00:00 EST 1999 · Journal of Materials Science. Materials in Medicine · OSTI ID:1817109

Oku, T; Suganuma, K; Wallemberg, L R; +3 more

Interplay of strain and phase evolution of laser powder bed fusion Ti–6Al–4V

Journal Article · Sat Aug 27 00:00:00 EDT 2022 · Materials Science and Engineering. A, Structural Materials: Properties, Microstructure and Processing · OSTI ID:1817109

Andrews, Caleb; Heo, T. W.; Shi, R.; +4 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
pedicle screw implant
additive manufacturing
bioactive glass
osseointegration
stress-shielding effect
X-ray tomography

Title: Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite

Citation Formats

References (51)

Similar Records

Related Subjects