Structural Connectivity-Based Parcellation of the Dopaminergic Midbrain in Healthy Subjects and Schizophrenic Patients

Basile, Gianpaolo Antonio; Bramanti, Alessia; Bertino, Salvatore; Cutroneo, Giuseppina; Bruno, Antonio; Tisano, Adriana; Paladina, Giuseppe; Milardi, Demetrio; Anastasi, Giuseppe

doi:10.3390/medicina56120686

Title: Structural Connectivity-Based Parcellation of the Dopaminergic Midbrain in Healthy Subjects and Schizophrenic Patients

Journal Article · Thu Dec 10 00:00:00 EST 2020 · Medicina

DOI:https://doi.org/10.3390/medicina56120686· OSTI ID:1816796

Basile, Gianpaolo Antonio ^[1]; Bramanti, Alessia ^[2]; Bertino, Salvatore ^[1]; Cutroneo, Giuseppina ^[1]; Bruno, Antonio ^[3]; Tisano, Adriana ^[4]; Paladina, Giuseppe ^[2]; Milardi, Demetrio ^[5]; Anastasi, Giuseppe ^[1]

Univ. of Messina (Italy). Dept. of Biomedical, Dental Sciences and Morphological and Functional Images. Brain Mapping Lab
IRCCS Centro Neurolesi “Bonino Pulejo”, Messina (Italy)
Univ. of Messina (Italy). Dept. of Biomedical, Dental Sciences and Morphological and Functional Images. Psychiatry Unit
Univ. Hospital G. Martino, Messina (Italy). Physical, Rehabilitation Medicine and Sport Medicine Unit
Univ. of Messina (Italy). Dept. of Biomedical, Dental Sciences and Morphological and Functional Images. Brain Mapping Lab; IRCCS Centro Neurolesi “Bonino Pulejo”, Messina (Italy)

Background and objectives: Functional deregulation of dopaminergic midbrain regions is a core feature of schizophrenia pathophysiology. Anatomical research on primates suggests that these regions may be subdivided into distinct, topographically organized functional territories according to their connectivity to the striatum. The aim of the present work was the reconstruction of dopaminergic midbrain subregions in healthy subjects and schizophrenic patients and the evaluation of their structural connectivity profiles. Materials and Methods: A hypothesis-driven connectivity-based parcellation derived from diffusion tractography was applied on 24 healthy subjects and 30 schizophrenic patients to identify distinct territories within the human dopaminergic midbrain in vivo and non-invasively. Results: We identified a tripartite subdivision of dopaminergic midbrain, including limbic, prefrontal and sensorimotor territories. No significant differences in structural features or connectivity were found between subjects and patients. Conclusions: The parcellation scheme proposed herein may help to achieve detailed characterization of structural and functional anomalies of the dopaminergic midbrain in schizophrenic patients.

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Research Organization:: The Mind Research Network, Albuquerque, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: FG02-08ER64581

OSTI ID:: 1816796

Journal Information:: Medicina, Vol. 56, Issue 12; ISSN 1648-9144

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
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Title: Structural Connectivity-Based Parcellation of the Dopaminergic Midbrain in Healthy Subjects and Schizophrenic Patients

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