Effects of chronic exposure to low levels of IR on Medaka ( Oryzias latipes ): a proteomic and bioinformatic approach

Perez-Gelvez, Yeni Natalia C.; Camus, Alvin C.; Bridger, Robert; Wells, Lance; Rhodes, Jr., Olin E.; Bergmann, Carl W.

doi:10.1080/09553002.2021.1962570

Title: Effects of chronic exposure to low levels of IR on Medaka ( Oryzias latipes ): a proteomic and bioinformatic approach

Journal Article · Tue Aug 17 00:00:00 EDT 2021 · International Journal of Radiation Biology

DOI:https://doi.org/10.1080/09553002.2021.1962570· OSTI ID:1813623

^[1]; Camus, Alvin C. ^[2]; Bridger, Robert ^[3]; Wells, Lance ^[3]; Rhodes, Jr., Olin E. ^[4]; Bergmann, Carl W. ^[3]

Carbohydrate Complex Research Center, Biochemistry and Molecular Biology, The University of Georgia, Athens, GA, USA
College of Veterinary Medicine, Department of Pathology, The University of Georgia, Athens, GA, USA
Carbohydrate Complex Research Center, The University of Georgia, Athens, GA, USA
Savannah River Ecology Laboratory, Odum School of Ecology, The University of Georgia, Athens, GA, USA

Purpose: Chronic exposure to ionizing radiation (IR) at low doses (<100 mGy) has been insufficiently studied to understand fully the risk to health. Relatively little knowledge exists regarding how species and healthy tissues respond at the protein level to chronic exposure to low doses of IR, and mass spectrometric-based profiling of protein expression is a powerful tool for studying changes in protein abundance. Materials and methods: SDS gel electrophoresis, LC-MS/MS mass spectrometry-based approaches and bioinformatic data analytics were used to detect proteomic changes following chronic exposure to moderate/low doses of radiation in adults and normally developed Medaka fish (Oryzias latipes). Results: Significant variations in the abundance of proteins involved in thyroid hormone signaling and lipid metabolism were detected, which could be related to the gonadal regression phenotype observed after 21.04 mGy and 204.3 mGy/day exposure. The global proteomic change was towards overexpression of proteins in muscle and skin, while the opposite effect was observed in internal organs. Conclusion: The present study provides information on the impacts of biologically relevant low doses of IR, which will be useful in future research for the identification of potential biomarkers of IR exposure and allow for a better assessment of radiation biosafety regulations.

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Research Organization:: Savannah River Ecology Laboratory (SREL), Aiken, SC (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: FC09-07SR22506; EM0004391

OSTI ID:: 1813623

Alternate ID(s):: OSTI ID: 1814634

Journal Information:: International Journal of Radiation Biology, Journal Name: International Journal of Radiation Biology Vol. 97 Journal Issue: 10; ISSN 0955-3002

Publisher:: Informa UK LimitedCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Title: Effects of chronic exposure to low levels of IR on Medaka ( Oryzias latipes ): a proteomic and bioinformatic approach

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