Review of advances in the development of laccases for the valorization of lignin to enable the production of lignocellulosic biofuels and bioproducts

Leynaud Kieffer Curran, Laure M. C.; Pham, Le Thanh Mai; Sale, Kenneth L.; Simmons, Blake A.

doi:10.1016/j.biotechadv.2021.107809

Title: Review of advances in the development of laccases for the valorization of lignin to enable the production of lignocellulosic biofuels and bioproducts

Journal Article · Sat Jan 01 00:00:00 EST 2022 · Biotechnology Advances

DOI:https://doi.org/10.1016/j.biotechadv.2021.107809· OSTI ID:1811710

Leynaud Kieffer Curran, Laure M. C.; Pham, Le Thanh Mai; Sale, Kenneth L.; Simmons, Blake A.

Development and deployment of commercial biorefineries based on conversion of lignocellulosic biomass into biofuels and bioproducts faces many challenges that must be addressed before they are commercially viable. One of the biggest challenges faced is the efficient and scalable valorization of lignin, one of the three major components of the plant cell wall. Lignin is the most abundant aromatic biopolymer on earth, and its presence hinders the extraction of cellulose and hemicellulose that is essential to biochemical conversion of lignocellulose to fuels and chemicals. There has been a significant amount of work over the past 20 years that has sought to develop innovative processes designed to extract and recycle lignin into valuable compounds and help reduce the overall costs of the biorefinery process. Due to the complex matrix of lignin, which is essential for plant survival, the development of a reliable and efficient lignin conversion technology has been difficult to achieve. One approach that has received significant interest relies on the use of enzymes, notably laccases, a class of multi-copper green oxidative enzymes that catalyze bond breaking in lignin to produce smaller oligomers. In this review, we first assess the different innovations of lignin valorization using laccases within the context of a biorefinery process, and then assess the latest economical advances that these innovations offered. Finally, we review laccase characterization and optimization, as well as the prospects and bottlenecks of this class of enzymes within the industrial and biorefining sectors.

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Research Organization:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1811710

Alternate ID(s):: OSTI ID: 1897721

Journal Information:: Biotechnology Advances, Journal Name: Biotechnology Advances Vol. 54 Journal Issue: C; ISSN 0734-9750

Publisher:: ElsevierCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Heterologous expression and characterization of a laccase from Laccaria bicolor in Pichia pastoris Wang, Bo; Wang, Xiuying; Tian, Yongsheng Biotechnology & Biotechnological Equipment, Vol. 30, Issue 1 https://doi.org/10.1080/13102818.2015.1104261	journal	November 2015
Application of eukaryotic and prokaryotic laccases in biosensor and biofuel cells: recent advances and electrochemical aspects Zhang, Yue; Lv, Ziyao; Zhou, Jie Applied Microbiology and Biotechnology, Vol. 102, Issue 24 https://doi.org/10.1007/s00253-018-9421-7	journal	October 2018
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Influence of iron and copper on the activity of laccases in Fusarium oxysporum f. sp. lycopersici Hernández-Monjaraz, Wendy Susana; Caudillo-Pérez, César; Salazar-Sánchez, Pedro Ulises Brazilian Journal of Microbiology, Vol. 49 https://doi.org/10.1016/j.bjm.2018.06.002	journal	November 2018
Oxidoreductases on their way to industrial biotransformations Martínez, Angel T.; Ruiz-Dueñas, Francisco J.; Camarero, Susana Biotechnology Advances, Vol. 35, Issue 6 https://doi.org/10.1016/j.biotechadv.2017.06.003	journal	November 2017
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Lignin-Derived Compounds as Efficient Laccase Mediators for Decolorization of Different Types of Recalcitrant Dyes Camarero, S.; Ibarra, D.; Martinez, M. J. Applied and Environmental Microbiology, Vol. 71, Issue 4 https://doi.org/10.1128/AEM.71.4.1775-1784.2005	journal	April 2005
The Structure of Rigidoporus lignosus Laccase Containing a Full Complement of Copper Ions, Reveals an Asymmetrical Arrangement for the T3 Copper Pair Garavaglia, Silvia; Teresa Cambria, Maria; Miglio, Marco Journal of Molecular Biology, Vol. 342, Issue 5 https://doi.org/10.1016/j.jmb.2004.07.100	journal	October 2004
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Tolerance engineering in bacteria for the production of advanced biofuels and chemicals Mukhopadhyay, Aindrila Trends in Microbiology, Vol. 23, Issue 8 https://doi.org/10.1016/j.tim.2015.04.008	journal	August 2015
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The white-rot fungus Cerrena unicolor strain 137 produces two laccase isoforms with different physico-chemical and catalytic properties Michniewicz, Anna; Ullrich, René; Ledakowicz, Stanisław Applied Microbiology and Biotechnology, Vol. 69, Issue 6 https://doi.org/10.1007/s00253-005-0015-9	journal	February 2006
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