Challenges and Opportunities in Biological Funneling of Heterogeneous and Toxic Substrates Beyond Lignin

Borchert, Andrew J.; Henson, William R.; Beckham, Gregg T.

doi:10.1016/j.copbio.2021.06.007

Title: Challenges and Opportunities in Biological Funneling of Heterogeneous and Toxic Substrates Beyond Lignin

Journal Article · Tue Jul 06 00:00:00 EDT 2021 · Current Opinion in Biotechnology

DOI:https://doi.org/10.1016/j.copbio.2021.06.007· OSTI ID:1808495

Borchert, Andrew J.;

;

Significant developments in the understanding and manipulation of microbial metabolism have enabled the use of engineered biological systems toward a more sustainable energy and materials economy. While developments in metabolic engineering have primarily focused on the conversion of carbohydrates, substantial opportunities exist for using these same principles to extract value from more heterogeneous and toxic waste streams, such as those derived from lignin, biomass pyrolysis, or industrial waste. Funneling heterogeneous substrates from these streams toward valuable products, termed biological funneling, presents new challenges in balancing multiple catabolic pathways competing for shared cellular resources and engineering against perturbation from toxic substrates. Solutions to many of these challenges have been explored within the field of lignin valorization. This perspective aims to extend beyond lignin to highlight the challenges and discuss opportunities for use of biological systems to upgrade previously inaccessible waste streams.

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Research Organization:: National Renewable Energy Lab. (NREL), Golden, CO (United States)

Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Transportation Office. Bioenergy Technologies Office

DOE Contract Number:: DE-AC36-08GO28308

OSTI ID:: 1808495

Report Number(s):: NREL/JA-2A00-80221; MainId:42424; UUID:66e685ae-ca4a-4992-8c14-c493793e6789; MainAdminID:25797

Journal Information:: Current Opinion in Biotechnology, Vol. 73

Country of Publication:: United States

Language:: English

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