Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

Bär, Christian; Chatterjee, Shambhabi; Falcão Pires, Inês; Rodrigues, Patrícia; Sluijter, Joost P. G.; Boon, Reinier A.; Nevado, Rosa M.; Andrés, Vicente; Sansonetti, Marida; de Windt, Leon; Ciccarelli, Michele; Hamdani, Nazha; Heymans, Stephane; Figuinha Videira, Raquel; Tocchetti, Carlo G.; Giacca, Mauro; Zacchigna, Serena; Engelhardt, Stefan; Dimmeler, Stefanie; Madonna, Rosalinda; Thum, Thomas

doi:10.1093/cvr/cvaa195

Title: Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

Journal Article · Wed Jul 08 00:00:00 EDT 2020 · Cardiovascular Research

DOI:https://doi.org/10.1093/cvr/cvaa195· OSTI ID:1650701

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Institute for Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany, REBIRTH Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany
Cardiovascular Research and Development Center, Faculty of Medicine, University of Porto, Porto, Portugal
Experimental Cardiology Laboratory, UMC Utrecht Regenerative Medicine Center, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands
Department of Physiology, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands, Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany, Partner site Rhein/Main, German Center for Cardiovascular Research (DZHK), Frankfurt am Main, Germany
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain, Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain
Institute for Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany, REBIRTH Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany, Department of Molecular Genetics, Faculty of Science and Engineering, Maastricht University, Maastricht, The Netherlands, Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
Department of Molecular Genetics, Faculty of Science and Engineering, Maastricht University, Maastricht, The Netherlands, Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
Department of Medicine, Surgery and Dentistry, University of Salerno, Italy
Department of Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany, Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany
Department of Cardiology, Maastricht University Medical Centre, University Hospital Maastricht, The Netherlands, Center for Heart Failure Research, Cardiovascular Research Institute Maastricht (CARIM), University Hospital Maastricht, The Netherlands
Cardiovascular Research and Development Center, Faculty of Medicine, University of Porto, Porto, Portugal, Department of Molecular Genetics, Faculty of Science and Engineering, Maastricht University, Maastricht, The Netherlands, Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
Department of Translational Medical Sciences and Interdepartmental Center of Clinical and Translational Research (CIRCET), Federico II University, Naples, Italy
International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy, School of Cardiovascular Medicine & Sciences, King’s College London, London, UK, Department of Medicine, Surgery and Health Sciences, University of Trieste, Italy
International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy, Department of Medicine, Surgery and Health Sciences, University of Trieste, Italy
Institute of Pharmacology and Toxicology, Technische Universität München, Biedersteiner Str. 29, Munich 80802, Germany, DZHK (German Center for Cardiovascular Research), Partner site Munich Heart Alliance, Biedersteiner Str. 29, Munich 80802, Germany
Institute for Cardiovascular Regeneration, Goethe University, Germany, German Center for Cardiovascular Research (DZHK), Frankfurt, Germany, Cardio-Pulmonary Institute (CPI), Frankfurt, Germany
Institute of Cardiology, University of Pisa, Pisa, Italy, Department of Internal Medicine, University of Texas Medical School, Houston, TX, USA

Abstract Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.

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Sponsoring Organization:: USDOE Office of Nuclear Energy (NE), Nuclear Fuel Cycle and Supply Chain

Grant/Contract Number:: SFRH/BD/96026/2013; 549901_2020_Madonna

OSTI ID:: 1650701

Journal Information:: Cardiovascular Research, Journal Name: Cardiovascular Research Vol. 116 Journal Issue: 11; ISSN 0008-6363

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Intercellular communication lessons in heart failure: Communication in heart failure Bang, Claudia; Antoniades, Charalambos; Antonopoulos, Alexios S. European Journal of Heart Failure, Vol. 17, Issue 11 https://doi.org/10.1002/ejhf.399	journal	September 2015
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC Ponikowski, Piotr; Voors, Adriaan A.; Anker, Stefan D. European Heart Journal, Vol. 37, Issue 27 https://doi.org/10.1093/eurheartj/ehw128	journal	May 2016
Obestatin attenuated doxorubicin-induced cardiomyopathy via enhancing long noncoding Mhrt RNA expression Li, Hong-qi; Wu, Yuan-bo; Yin, Chang-sen Biomedicine & Pharmacotherapy, Vol. 81 https://doi.org/10.1016/j.biopha.2016.04.017	journal	July 2016

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