Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements

Khashaba, Rania M.; Moussa, Mervet; Koch, Christopher; Jurgensen, Arthur R.; Missimer, David M.; Rutherford, Ronny L.; Chutkan, Norman B.; Borke, James L.

doi:10.1155/2011/467641

Title: Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements

Journal Article · Sun Sep 11 00:00:00 EDT 2011 · International Journal of Biomaterials

DOI:https://doi.org/10.1155/2011/467641· OSTI ID:1628986

Khashaba, Rania M. ^[1]; Moussa, Mervet ^[2]; Koch, Christopher ^[3]; Jurgensen, Arthur R. ^[4]; Missimer, David M. ^[4]; Rutherford, Ronny L. ^[5]; Chutkan, Norman B. ^[3]; Borke, James L. ^[6]

Medical College of Georgia, Augusta, GA (United States). Dept. of Oral Biology; Medical College of Georgia, Augusta, GA (United States). Dept. of Orthopaedic Surgery, Section of Biomaterials; Misr International Univ. (MIU), Cairo (Egypt). Dept. of Dental Materials
Cairo Univ., Cairo (Egypt). Dept. of Oral Pathology; Misr International University (MIU), Cairo (Egypt). Dept. of Oral Pathology
Medical College of Georgia, Augusta, GA (United States). Dept. of Orthopaedic Surgery, Section of Biomaterials
Savannah River Nuclear Solutions, Aiken, SC (United States)
Savannah River National Laboratory, Savannah River Nuclear Solutions, Aiken, SC 29808, USA
Medical College of Georgia, Augusta, GA (United States). Dept. of Oral Biology; Medical College of Georgia, Augusta, GA (United States). Dept. of Orthopaedic Surgery, Section of Biomaterials

Aim. Physicochemical mechanical and in vitro biological properties of novel formulations of polymeric calcium phosphate cements (CPCs) were investigated. Methods. Monocalcium phosphate, calcium oxide, and synthetic hydroxyapatite were combined with either modified polyacrylic acid, light activated polyalkenoic acid, or polymethyl vinyl ether maleic acid to obtain Types I, II, and III CPCs. Setting time, compressive and diametral strength of CPCs was compared with zinc polycarboxylate cement (control). Specimens were characterized using X-ray diffraction, scanning electron microscopy, and infrared spectroscopy. In vitro cytotoxicity of CPCs and control was assessed. Results. X-ray diffraction analysis showed hydroxyapatite, monetite, and brushite. Acid-base reaction was confirmed by the appearance of stretching peaks in IR spectra of set cements. SEM revealed rod-like crystals and platy crystals. Setting time of cements was 5–12 min. Type III showed significantly higher strength values compared to control. Type III yielded high biocompatibility. Conclusions. Type III CPCs show promise for dental applications.

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Research Organization:: Medical College of Georgia, Augusta, GA (United States); Savannah River National Laboratory (SRNL), Aiken, SC (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI ID:: 1628986

Journal Information:: International Journal of Biomaterials, Vol. 2011; ISSN 1687-8787

Publisher:: HindawiCopyright Statement

Country of Publication:: United States

Language:: English

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