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Title: The Role of inab in Axon Morphology of an Identified Zebrafish Motoneuron

Journal Article · · PLoS ONE
 [1];  [1];  [1]
  1. University of Oregon, Eugene, OR (United States)
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The ability of an animal to move and to interact with its environment requires that motoneurons correctly innervate specific muscles. Although many genes that regulate motoneuron development have been identified, our understanding of motor axon branching remains incomplete. We used transcriptional expression profiling to identify potential candidate genes involved in development of zebrafish identified motoneurons. Here we focus on inab, an intermediate filament encoding gene dynamically expressed in a subset of motoneurons as well as in an identified interneuron. We show that inab is necessary for proper axon morphology of a specific motoneuron subtype.

Research Organization:
Univ. of Oregon, Eugene, OR (United States)
Sponsoring Organization:
National Institutes of Health (NIH)
DOE Contract Number:
NS23915; HD007348
OSTI ID:
1627679
Journal Information:
PLoS ONE, Vol. 9, Issue 2; ISSN 1932-6203
Publisher:
Public Library of Science
Country of Publication:
United States
Language:
English

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Cited By (1)

Distribution patterns of the zebrafish neuronal intermediate filaments inaa and inab journal October 2018

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59 BASIC BIOLOGICAL SCIENCES
axons
spinal cord
zebrafish
gene expression
interneurons
microarrays
intermediate filaments
RNA hybridization