Temporally selective contextual encoding in the dentate gyrus of the hippocampus
- Univ. of California, San Diego, CA (United States). program in Neurosciences; Salk Institute for Biological Studies, La Jolla, CA (United States)
- Univ. of California, San Diego, CA (United States). Dept. of Cognitive Science
- Salk Institute for Biological Studies, La Jolla, CA (United States)
- Univ. of Queensland, Brisbane, QLD (Australia). School of Information Technology and Electrical Engineering
- Univ. of California, San Diego, CA (United States). program in Neurosciences; Univ. of California, San Diego, CA (United States). Dept. of Cognitive Science
A recent model of the hippocampus predicts that the unique properties of the dentate gyrus allow for temporal separation of events. This temporal separation is accomplished in part through the continual generation of new neurons, which, due to a transient window of hyperexcitability, could allow for preferential encoding of information present during their development. Here we obtain in vivo electrophysiological recordings and identify a cell population exhibiting activity that is selective to single contexts when rats experience a long temporal separation between context exposures during training. This selectivity is attenuated as the temporal separation between context exposures is shortened and is further attenuated when neurogenesis is reduced. Our data reveal the existence of a temporal orthogonalizing neuronal code within the dentate gyrus, a hallmark feature of episodic memory.
- Research Organization:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division; National Science Foundation (NSF)
- Grant/Contract Number:
- NA0003525; SBE 0542013
- OSTI ID:
- 1623933
- Journal Information:
- Nature Communications, Vol. 5, Issue 1; ISSN 2041-1723
- Publisher:
- Nature Publishing GroupCopyright Statement
- Country of Publication:
- United States
- Language:
- English
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