Structural characterization of [beta];#8208;ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites

Patterson, Edward I.; Nanson, Jeffrey D.; Abendroth, Jan; Bryan, Cassie; Sankaran, Banumathi; Myler, Peter J.; Forwood, Jade K.

doi:10.1002/prot.25765

Title: Structural characterization of [beta];#8208;ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites

Journal Article · Tue Jan 21 00:00:00 EST 2020 · Proteins

DOI:https://doi.org/10.1002/prot.25765· OSTI ID:1593427

Patterson, Edward I.; Nanson, Jeffrey D.; Abendroth, Jan; Bryan, Cassie; Sankaran, Banumathi; Myler, Peter J.; Forwood, Jade K. ^[1]

LBNL

Cite

Export

Save

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: NIAIDNIH

OSTI ID:: 1593427

Journal Information:: Proteins, Vol. 88, Issue (1) ; 01, 2020

Country of Publication:: United States

Language:: ENGLISH

References (42)

The architectures of iterative type I PKS and FAS Herbst, Dominik A.; Townsend, Craig A.; Maier, Timm Natural Product Reports, Vol. 35, Issue 10 https://doi.org/10.1039/C8NP00039E	journal	January 2018
Perspectives on the evolution, assembly and conformational dynamics of fatty acid synthase type I (FAS I) systems Grininger, Martin Current Opinion in Structural Biology, Vol. 25 https://doi.org/10.1016/j.sbi.2013.12.004	journal	April 2014
The Structural Biology of type ii Fatty acid Biosynthesis White, Stephen W.; Zheng, Jie; Zhang, Yong-Mei Annual Review of Biochemistry, Vol. 74, Issue 1 https://doi.org/10.1146/annurev.biochem.74.082803.133524	journal	June 2005
Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering Beld, Joris; Lee, D. John; Burkart, Michael D. Molecular BioSystems, Vol. 11, Issue 1 https://doi.org/10.1039/C4MB00443D	journal	January 2015
The X-ray crystal structure of β-ketoacyl [acyl carrier protein] synthase I Olsen, Johan Gotthardt; Kadziola, Anders; von Wettstein-Knowles, Penny FEBS Letters, Vol. 460, Issue 1 https://doi.org/10.1016/S0014-5793(99)01303-4	journal	October 1999
The 1.3-Angstrom-Resolution Crystal Structure of -Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae Price, A. C.; Rock, C. O.; White, S. W. Journal of Bacteriology, Vol. 185, Issue 14 https://doi.org/10.1128/JB.185.14.4136-4143.2003	journal	July 2003
Crystal structure of beta -ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes Huang, W. The EMBO Journal, Vol. 17, Issue 5 https://doi.org/10.1093/emboj/17.5.1183	journal	March 1998
The 1.8 Å crystal structure and active-site architecture of β-ketoacyl-acyl carrier protein synthase III (FabH) from Escherichia coli Davies, Christopher; Heath, Richard J.; White, Stephen W. Structure, Vol. 8, Issue 2 https://doi.org/10.1016/S0969-2126(00)00094-0	journal	February 2000
Structural characterisation of the fatty acid biosynthesis enzyme FabF from the pathogen Listeria monocytogenes Soares da Costa, Tatiana P.; Nanson, Jeffrey D.; Forwood, Jade K. Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/srep39277	journal	January 2017
Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases von Wettstein-Knowles, Penny; Olsen, Johan G.; McGuire, Kirsten A. FEBS Journal, Vol. 273, Issue 4 https://doi.org/10.1111/j.1742-4658.2005.05101.x	journal	February 2006
Inhibition of β-Ketoacyl-Acyl Carrier Protein Synthases by Thiolactomycin and Cerulenin: STRUCTURE AND MECHANISM Price, Allen C.; Choi, Keum-Hwa; Heath, Richard J. Journal of Biological Chemistry, Vol. 276, Issue 9 https://doi.org/10.1074/jbc.M007101200	journal	October 2000
Crystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Luckner, Sylvia R.; Machutta, Carl A.; Tonge, Peter J. Structure, Vol. 17, Issue 7 https://doi.org/10.1016/j.str.2009.04.012	journal	July 2009
Structural basis and mechanism of enoyl reductase inhibition by triclosan Stewart, Michael J.; Parikh, Sapan; Xiao, Guoping Journal of Molecular Biology, Vol. 290, Issue 4 https://doi.org/10.1006/jmbi.1999.2907	journal	April 1999
The mshA gene encoding the glycosyltransferase of mycothiol biosynthesis is essential in Mycobacterium tuberculosis Erdman Buchmeier, Nancy; Fahey, Robert C. FEMS Microbiology Letters, Vol. 264, Issue 1 https://doi.org/10.1111/j.1574-6968.2006.00441.x	journal	November 2006
Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach Chollet, Aurélien; Mourey, Lionel; Lherbet, Christian Journal of Structural Biology, Vol. 190, Issue 3 https://doi.org/10.1016/j.jsb.2015.04.008	journal	June 2015
Escherichia coli Unsaturated Fatty Acid Synthesis: COMPLEX TRANSCRIPTION OF THE fabA GENE AND IN VIVO IDENTIFICATION OF THE ESSENTIAL REACTION CATALYZED BY FabB Feng, Youjun; Cronan, John E. Journal of Biological Chemistry, Vol. 284, Issue 43 https://doi.org/10.1074/jbc.M109.023440	journal	August 2009
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties Wang, J.; Kodali, S.; Lee, S. H. Proceedings of the National Academy of Sciences, Vol. 104, Issue 18 https://doi.org/10.1073/pnas.0700746104	journal	April 2007
Platensimycin is a selective FabF inhibitor with potent antibiotic properties Wang, Jun; Soisson, Stephen M.; Young, Katherine Nature, Vol. 441, Issue 7091 https://doi.org/10.1038/nature04784	journal	May 2006
Potent growth inhibitory activity of (±)-platencin towards multi-drug-resistant and extensively drug-resistant Mycobacterium tuberculosis Moustafa, Gamal A. I.; Nojima, Shoji; Yamano, Yoshi MedChemComm, Vol. 4, Issue 4 https://doi.org/10.1039/c3md00016h	journal	January 2013
Brucellosis Pappas, Georgios; Akritidis, Nikolaos; Bosilkovski, Mile New England Journal of Medicine, Vol. 352, Issue 22 https://doi.org/10.1056/NEJMra050570	journal	June 2005
The new global map of human brucellosis Pappas, Georgios; Papadimitriou, Photini; Akritidis, Nikolaos The Lancet Infectious Diseases, Vol. 6, Issue 2 https://doi.org/10.1016/S1473-3099(06)70382-6	journal	February 2006
Brucellosis: A re-emerging zoonosis Seleem, Mohamed N.; Boyle, Stephen M.; Sriranganathan, Nammalwar Veterinary Microbiology, Vol. 140, Issue 3-4 https://doi.org/10.1016/j.vetmic.2009.06.021	journal	January 2010
Review of clinical and laboratory features of human Brucellosis Mantur, Bg; Amarnath, Sk; Shinde, Rs Indian Journal of Medical Microbiology, Vol. 25, Issue 3 https://doi.org/10.4103/0255-0857.34758	journal	January 2007
Brucella Endocarditis: Clinical, Diagnostic, and Therapeutic Approach Reguera, J. M.; Alarc�n, A.; Miralles, F. European Journal of Clinical Microbiology & Infectious Diseases, Vol. 22, Issue 11 https://doi.org/10.1007/s10096-003-1026-z	journal	November 2003
Doxycycline-rifampin versus doxycycline-streptomycin in treatment of human brucellosis due to Brucella melitensis. The GECMEI Group. Grupo de Estudio de Castilla-la Mancha de Enfermedades Infecciosas Solera, J.; Rodriguez-Zapata, M.; Geijo, P. Antimicrobial Agents and Chemotherapy, Vol. 39, Issue 9 https://doi.org/10.1128/AAC.39.9.2061	journal	September 1995
Targeting Brucella melitensis with polymeric nanoparticles containing streptomycin and doxycycline Seleem, Mohamed N.; Jain, Neeta; Pothayee, Nikorn FEMS Microbiology Letters, Vol. 294, Issue 1 https://doi.org/10.1111/j.1574-6968.2009.01530.x	journal	May 2009
Combining Functional and Structural Genomics to Sample the Essential Burkholderia Structome Baugh, Loren; Gallagher, Larry A.; Patrapuvich, Rapatbhorn PLoS ONE, Vol. 8, Issue 1 https://doi.org/10.1371/journal.pone.0053851	journal	January 2013
Structural Insights into the Mechanism and Inhibition of the β-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonas aeruginosa Moynié, Lucile; Leckie, Stuart M.; McMahon, Stephen A. Journal of Molecular Biology, Vol. 425, Issue 2 https://doi.org/10.1016/j.jmb.2012.11.017	journal	January 2013
Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase Werther, Tobias; Wahlefeld, Stefan; Salewski, Johannes Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/ncomms16084	journal	July 2017
Ligation-independent cloning of PCR products (LIC-PCR) Aslanidis, Charalampos; de Jong, Pieter J. Nucleic Acids Research, Vol. 18, Issue 20 https://doi.org/10.1093/nar/18.20.6069	journal	January 1990
Immobilized metal-affinity chromatography protein-recovery screening is predictive of crystallographic structure success Choi, Ryan; Kelley, Angela; Leibly, David Acta Crystallographica Section F Structural Biology and Crystallization Communications, Vol. 67, Issue 9 https://doi.org/10.1107/S1744309111017374	journal	August 2011
High-throughput protein production and purification at the Seattle Structural Genomics Center for Infectious Disease Bryan, Cassie M.; Bhandari, Janhavi; Napuli, Alberto J. Acta Crystallographica Section F Structural Biology and Crystallization Communications, Vol. 67, Issue 9 https://doi.org/10.1107/S1744309111018367	journal	August 2011
XDS Kabsch, Wolfgang Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2 https://doi.org/10.1107/S0907444909047337	journal	January 2010
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
The CCP4 suite programs for protein crystallography Acta Crystallographica Section D Biological Crystallography, Vol. 50, Issue 5, p. 760-763 https://doi.org/10.1107/S0907444994003112	journal	September 1994
CHAINSAW : a program for mutating pdb files used as templates in molecular replacement Stein, Norman Journal of Applied Crystallography, Vol. 41, Issue 3 https://doi.org/10.1107/S0021889808006985	journal	April 2008
Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7 Langer, Gerrit; Cohen, Serge X.; Lamzin, Victor S. Nature Protocols, Vol. 3, Issue 7 https://doi.org/10.1038/nprot.2008.91	journal	June 2008
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
REFMAC 5 dictionary: organization of prior chemical knowledge and guidelines for its use Vagin, Alexei A.; Steiner, Roberto A.; Lebedev, Andrey A. Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12 https://doi.org/10.1107/S0907444904023510	journal	November 2004
Dali server update Holm, Liisa; Laakso, Laura M. Nucleic Acids Research, Vol. 44, Issue W1 https://doi.org/10.1093/nar/gkw357	journal	April 2016
Inference of Macromolecular Assemblies from Crystalline State Krissinel, Evgeny; Henrick, Kim Journal of Molecular Biology, Vol. 372, Issue 3 https://doi.org/10.1016/j.jmb.2007.05.022	journal	September 2007
Roles of the Active Site Water, Histidine 303, and Phenylalanine 396 in the Catalytic Mechanism of the Elongation Condensing Enzyme of Streptococcus pneumoniae Zhang, Yong-Mei; Hurlbert, Jason; White, Stephen W. Journal of Biological Chemistry, Vol. 281, Issue 25 https://doi.org/10.1074/jbc.M513199200	journal	April 2006

Similar Records

A human ;#8203;fatty acid synthase inhibitor binds [beta]-ketoacyl reductase in the keto-substrate site

Journal Article · Mon Oct 27 00:00:00 EDT 2014 · Nat. Chem. Biol. · OSTI ID:1593427

Hardwicke, Mary Ann; Rendina, Alan R.; Williams, Shawn P.; +10 more

Improved chemical and isotopic labeling of biomembranes in Bacillus subtilis by leveraging CRISPRi inhibition of beta-ketoacyl-ACP synthase (fabF)

Journal Article · Fri Oct 21 00:00:00 EDT 2022 · Frontiers in Molecular Biosciences · OSTI ID:1593427

Nickels, Jonathan D.; Bonifer, Kyle S.; Tindall, Rachel R.; +5 more

Modulation of medium-chain fatty acid synthesis in Synechococcus sp. PCC 7002 by replacing FabH with a Chaetoceros Ketoacyl-ACP synthase

Journal Article · Thu May 26 00:00:00 EDT 2016 · Frontiers in Plant Science · OSTI ID:1593427

Gu, Huiya; Jinkerson, Robert E.; Davies, Fiona K.; +3 more

Title: Structural characterization of [beta];#8208;ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites

Citation Formats

References (42)

Similar Records

Related Subjects