Interpreting Mammalian Evolution using Fugu Genome Comparisons
Journal Article
·
· Genomics
OSTI ID:15013863
Comparative sequence analysis of the human and the pufferfish Fugu rubripes (fugu) genomes has revealed several novel functional coding and noncoding regions in the human genome. In particular, the fugu genome has been extremely valuable for identifying transcriptional regulatory elements in human loci harboring unusually high levels of evolutionary conservation to rodent genomes. In such regions, the large evolutionary distance between human and fishes provides an additional filter through which functional noncoding elements can be detected with high efficiency.
- Research Organization:
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 15013863
- Report Number(s):
- UCRL-JRNL-203427; GNMCEP; TRN: US200803%%950
- Journal Information:
- Genomics, Journal Issue: 5; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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