Protein evolution on partially correlated landscapes

Journal Article · Tue Oct 10 00:00:00 EDT 1995 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.92.21.9657· OSTI ID:146516

Perelson, A S; Macken, C A ^[1]

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1. Los Alamos National Lab., NM (United States)

We extend an earlier model of protein evolution on a rugged landscape to the case in which the landscape exhibits a variable degree of correlation (i.e., smoothness). Correlation is introduced by assuming that a protein is composed of a set of independent blocks or domains and that mutation in one block affects the contribution of that block alone to the overall fitness of the protein. We study the statistical structure of such landscapes and apply our theory to the evolution by somatic hypermutation of antibody molecules composed of framework and complementarity-determining regions. We predict the expected number of replacement mutations in each region. 40 refs., 3 figs.

• Sponsoring Organization: USDOE
• OSTI ID: 146516
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 21; Other Information: PBD: 10 Oct 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
MOLECULAR STRUCTURE
BIOLOGICAL PATHWAYS
EVALUATION
PROTEINS