Toxic heavy metal – Pb, Cd, Sn – complexation by the octadentate hydroxypyridinonate ligand archetype 3,4,3-LI(1,2-HOPO)

Deblonde, Gauthier J. -P.; Lohrey, Trevor D.; An, Dahlia D.; Abergel, Rebecca J.

doi:10.1039/c7nj04559j

Title: Toxic heavy metal – Pb, Cd, Sn – complexation by the octadentate hydroxypyridinonate ligand archetype 3,4,3-LI(1,2-HOPO)

Journal Article · Fri Feb 02 00:00:00 EST 2018 · New Journal of Chemistry

DOI:https://doi.org/10.1039/c7nj04559j· OSTI ID:1458507

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Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Chemical Sciences Division
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Chemical Sciences Division; Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Chemical Sciences Division; Univ. of California, Berkeley, CA (United States). Dept. of Nuclear Engineering

The toxicity of heavy metals such as lead (Pb), cadmium (Cd) and tin (Sn) has long been known but accidental exposures of large populations to these elements remain unfortunately a topical issue. Chelating agents against Pb, Cd, or Sn poisoning are still limited to classical ligands such as ethylenediamine tetraacetic acid (EDTA). In this paper, we evaluate the ability of 3,4,3-LI(1,2-HOPO) (L^4-), an octadentate ligand currently under evaluation for actinide decorporation, to bind Pb, Cd and Sn metal ions in aqueous solutions. This ligand forms 1 : 1 complexes with Pb(II), Cd(II) and Sn(IV) as well as bimetallic 2 : 1 species with Pb(II) and Cd(II), all of which were characterized by high resolution mass spectrometry and spectrophotometric titrations. The 3,4,3-LI(1,2-HOPO) ligand exhibits an extreme affinity for Sn(IV) ions (log β₁₁₀ > 40), with the complex remaining stable from highly acidic conditions to alkaline media (from 3 M HCl to pH 8). Single crystals of the neutral complex [Sn^IV3,4,3-LI(1,2-HOPO)·3H₂O] were obtained and its structure determined, revealing a chiral conformation. Finally, although not initially designed for hexacoordinated metals such as Pb(II) and Cd(II), the octadentate ligand shows promise for the in vitro or in vivo sequestration of toxic heavy metals, as evidenced by decorporation experiments performed in mice contaminated with ²¹⁰Pb(II) and treated with either EDTA or 3,4,3-LI(1,2-HOPO).

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1458507

Journal Information:: New Journal of Chemistry, Vol. 42, Issue 10; ISSN 1144-0546

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 21 works

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