Cellular dosimetry: Absorbed fractions for monoenergetic electron and alpha particle sources and S-values for radionuclides uniformly distributed in different cell compartments
- Univ. of Medicine and Denistry of New Jersey, Newark (United States)
The importance of cellular dosimetry in both diagnostic and therapeutic nuclear medicine is becoming increasingly recognized. Experimental range-energy relations for electrons and alpha particles, along with derived geometric reduction factors, are used to calculate cellular absorbed fractions for these radiations. The resulting absorbed fractions are employed to calculate cellular S-values for several radionuclides. Cellular absorbed fractions for monoenergetic electron sources with energies ranging from 0.1 keV to 1 MeV, distributed uniformly in the source region, are calculated for several target {l_arrow} source combinations including cell{l_arrow}cell, cell{l_arrow}cell surface, nucleus{l_arrow}nucleus, nucleus {l_arrow}cytoplasm and nucleus {l_arrow}cell surface. Similar data are also provided for monoenergetic alpha particle sources with energies ranging from 3 to 10 MeV. S-values are also conveniently tabulated for {sup 32}P, {sup 35}S, {sup 86}Rb, {sup 89}Sr, {sup 90}Y, {sup 91}Y {sup 114M}In, {sup 131}I, Auger electron-emitters {sup 51}Cr, {sup 67}Ga, {sup 99m}Tc, {sup 111}In, {sup 123}I, {sup 201}Tl, {sup 203}Pb and the alpha emitter {sup 210}Po. In addition, S-values are given for radionuclides in the {sup 212}Pb decay series, including {sup 212}Pb, {sup 212}Bi and {sup 212}Po. Both absorbed fractions and S-values are supplied for a number of different size cells and cell nuclei. With the absorbed fractions and S-values in hand, along with experimentally determined information on the biokinetics and subcellular distribution of the radionuclides, the cellular self-absorbed dose can be conveniently calculated. 33 refs., 2 figs., 17 tabs.
- OSTI ID:
- 135837
- Journal Information:
- Journal of Nuclear Medicine Technology, Vol. 35, Issue 2; Other Information: PBD: Feb 1994
- Country of Publication:
- United States
- Language:
- English
Similar Records
Quantitative impact of changes in marrow cellularity, skeletal size, and bone mineral density on active marrow dosimetry based upon a reference model
Multicellular dosimetry for micrometastases: Dependence of self-dose versus cross-dose to cell nuclei on type and energy of radiation and subcellular distribution of radionuclides
Related Subjects
APPLIED STUDIES
ELECTRON SOURCES
SUBCELLULAR DISTRIBUTION
RADIATION DOSES
ALPHA SOURCES
ALPHA DOSIMETRY
ELECTRON DOSIMETRY
PHOSPHORUS 32
SULFUR 35
RUBIDIUM 86
STRONTIUM 89
YTTRIUM 90
YTTRIUM 91
INDIUM 114
IODINE 131
THALLIUM 201
CHROMIUM 51
GALLIUM 67
TECHNETIUM 99
INDIUM 111
IODINE 123
LEAD 203
POLONIUM 210
LEAD 212
BISMUTH 212
POLONIUM 212