Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
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journal
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September 2002 |
The polycomb group protein EZH2 is involved in progression of prostate cancer
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journal
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October 2002 |
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
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journal
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September 2004 |
The Murine Polycomb Group Protein Eed Is Required for Global Histone H3 Lysine-27 Methylation
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journal
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May 2005 |
The Polycomb complex PRC2 and its mark in life
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journal
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January 2011 |
Regulation of gene transcription by Polycomb proteins
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journal
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December 2015 |
PRC2 mediated H3K27 methylations in cellular identity and cancer
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journal
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December 2015 |
EZH2 in normal and malignant hematopoiesis
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journal
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October 2013 |
Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
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journal
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March 2013 |
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
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journal
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October 2012 |
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
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journal
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December 2012 |
An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
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journal
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April 2013 |
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity
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journal
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March 2015 |
Targeting EZH2 in cancer
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journal
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February 2016 |
Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2
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journal
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October 2015 |
Role of the polycomb protein EED in the propagation of repressive histone marks
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journal
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September 2009 |
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)
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journal
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October 2010 |
Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation
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journal
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March 2015 |
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
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journal
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April 2016 |
Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
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journal
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April 2016 |
International Union of Basic and Clinical Pharmacology. XC. Multisite Pharmacology: Recommendations for the Nomenclature of Receptor Allosterism and Allosteric Ligands
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journal
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July 2014 |
Targeting Methyl Lysine
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book
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January 2010 |
Epigenetic protein families: a new frontier for drug discovery
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journal
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April 2012 |
Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing
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journal
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July 2016 |
Structure–activity relationships of methyl-lysine reader antagonists
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journal
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January 2012 |
Competitive Binding of a Benzimidazole to the Histone-Binding Pocket of the Pygo PHD Finger
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journal
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October 2014 |
Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family
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journal
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December 2015 |
Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1
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journal
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January 2015 |
Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain
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journal
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February 2015 |
Identification and Characterization of Small Molecule Inhibitors of a Plant Homeodomain Finger
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journal
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October 2012 |
Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform
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journal
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February 2016 |
A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
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journal
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January 2016 |
Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase
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journal
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January 2017 |
Seamless Bead to Microarray Screening: Rapid Identification of the Highest Affinity Protein Ligands from Large Combinatorial Libraries
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journal
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January 2010 |
A new type of synthetic peptide library for identifying ligand-binding activity
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journal
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November 1991 |
Utility of Redundant Combinatorial Libraries in Distinguishing High and Low Quality Screening Hits
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journal
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March 2014 |
Synthesis and Screening of Stereochemically Diverse Combinatorial Libraries of Peptide Tertiary Amides
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journal
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March 2013 |
Rapid Lead Discovery Through Iterative Screening of One Bead One Compound Libraries
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journal
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December 2014 |
Rapid identification of orexin receptor binding ligands using cell-based screening accelerated with magnetic beads
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journal
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January 2010 |