Facile purification and click labeling with 2-[18F]fluoroethyl azide using solid phase extraction cartridges
Journal Article
·
· Tetrahedron Letters
- Washington Univ. School of Medicine, St. Louis, MO (United States)
- Washington Univ. School of Medicine, St. Louis, MO (United States); Univ. of Pennsylvania, Philadelphia, PA (United States)
- Univ. of Illinois, Urbana, IL (United States)
In this paper, a facile method was developed to purify 2-[18F]fluoroethyl azide ([18F]FEA) using a C18 cartridge and an Oasis® HLB cartridge in series, in which [18F]FEA was exclusively trapped on the HLB cartridge. [18F]FEA can be eluted for reactions in solution; alternatively click labeling can be carried out on the HLB cartridge itself by loading an alkyne substrate and copper (I) catalyst dissolved in DMF onto the cartridge. Finally, this solid phase extraction methodology for purification and click labeling with [18F]FEA, either in solution or on the cartridge, is safe, simple, reproducible in high yield, and compatible with automated synthesis of 18F-labeled PET tracers.
- Research Organization:
- Washington Univ., St. Louis, MO (United States). School of Medicine; Univ. of Illinois at Urbana-Champaign, IL (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC)
- Grant/Contract Number:
- SC0005434; SC0002032
- OSTI ID:
- 1344513
- Alternate ID(s):
- OSTI ID: 1366319
- Journal Information:
- Tetrahedron Letters, Vol. 56, Issue 7; ISSN 0040-4039
- Publisher:
- ElsevierCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Cited by: 14 works
Citation information provided by
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