The Monoamine Hypothesis of Depression
|
book
|
January 2005 |
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
|
journal
|
August 2010 |
Pharmacology and Functions of Metabotropic Glutamate Receptors
|
journal
|
April 1997 |
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
|
journal
|
October 1999 |
Group II metabotropic glutamate receptor agonists as a potential drug for schizophrenia
|
journal
|
August 2010 |
Metabotropic glutamate receptors as novel targets for anxiety and stress disorders
|
journal
|
January 2005 |
Glutamate-based antidepressants: 20 years on
|
journal
|
November 2009 |
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
|
journal
|
May 2008 |
Metabotropic Glutamate Receptors in the Control of Mood Disorders
|
journal
|
April 2007 |
Neuroprotection by metabotropic glutamate receptor agonists: LY354740, LY379268 and LY389795
|
journal
|
July 1999 |
Efficacy and Tolerability of an mGlu2/3 Agonist in the Treatment of Generalized Anxiety Disorder
|
journal
|
August 2007 |
Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial
|
journal
|
September 2007 |
AFQ056 in Parkinson patients with levodopa-induced dyskinesia: 13-week, randomized, dose-finding study: AFQ056 treatment of l -Dopa-Induced Dyskinesia
|
journal
|
July 2013 |
Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition
|
journal
|
March 2008 |
Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites
|
journal
|
September 2001 |
Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors
|
journal
|
September 2000 |
Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice
|
journal
|
May 2000 |
Evidence for the Role of Metabotropic Glutamate (mGlu)2 Not mGlu3 Receptors in the Preclinical Antipsychotic Pharmacology of the mGlu2/3 Receptor Agonist (–)-(1 R, 4 S ,5 S ,6 S )-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic Acid (LY404039)
|
journal
|
April 2008 |
mGlu2 Metabotropic Glutamate Receptors Restrain Inflammatory Pain and Mediate the Analgesic Activity of Dual mGlu2/mGlu3 Receptor Agonists
|
journal
|
January 2011 |
Metabotropic Glutamate Receptors Differentially Regulate GABAergic Inhibition in Thalamus
|
journal
|
December 2006 |
Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction
|
journal
|
January 2015 |
The Use of Knock-Out Mice Unravels Distinct Roles for mGlu2 and mGlu3 Metabotropic Glutamate Receptors in Mechanisms of Neurodegeneration/Neuroprotection
|
journal
|
August 2007 |
Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking mGluR2
|
journal
|
August 1996 |
Presynaptic Group II mGluR Inhibition of Short-Term Depression in the Medial Perforant Path of the Dentate Gyrus In Vitro
|
journal
|
June 2001 |
Cocaine and Kindling Alter the Sensitivity of Group II and III Metabotropic Glutamate Receptors in the Central Amygdala
|
journal
|
August 2000 |
Differential regulation of synaptic transmission by mGlu2 and mGlu3 at the perforant path inputs to the dentate gyrus and CA1 revealed in mGlu2 -/- mice
|
journal
|
August 2002 |
mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure
|
journal
|
January 2013 |
mTOR activation is required for the antidepressant effects of mGluR2/3 blockade
|
journal
|
November 2011 |
Role of BDNF/TrkB signaling in antidepressant-like effects of a group II metabotropic glutamate receptor antagonist in animal models of depression
|
journal
|
February 2013 |
The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN
|
journal
|
August 2015 |
Antidepressant effects of ketamine in depressed patients
|
journal
|
February 2000 |
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression
|
journal
|
August 2006 |
Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial
|
journal
|
February 2010 |
Ketamine for Depression: Where Do We Go from Here?
|
journal
|
October 2012 |
Ketamine for Treatment-Resistant Unipolar Depression: Current Evidence
|
journal
|
January 2012 |
Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial
|
journal
|
October 2013 |
2-Substituted (2 SR )-2-Amino-2-((1 SR ,2 SR )-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability
|
journal
|
January 1998 |
LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors
|
journal
|
January 1998 |
MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity
|
journal
|
March 2004 |
An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats
|
journal
|
April 2006 |
On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039
|
journal
|
August 2010 |
Recent Progress in the Synthesis and Characterization of Group II Metabotropic Glutamate Receptor Allosteric Modulators
|
journal
|
April 2011 |
Ketamine as a new treatment for depression: A review of its efficacy and adverse effects
|
journal
|
May 2013 |
Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties
|
journal
|
February 1997 |
LY354740 is a Potent and Highly Selective Group II Metabotropic Glutamate Receptor Agonist in Cells Expressing Human Glutamate Receptors
|
journal
|
January 1997 |
Synthesis and Metabotropic Glutamate Receptor Activity of S-Oxidized Variants of (−)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: Identification of Potent, Selective, and Orally Bioavailable Agonists for mGlu2/3 Receptors
|
journal
|
January 2007 |
Pharmacological and Pharmacokinetic Properties of a Structurally Novel, Potent, and Selective Metabotropic Glutamate 2/3 Receptor Agonist: In Vitro Characterization of Agonist (–)-(1 R ,4 S ,5 S ,6 S )-4-Amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic Acid (LY404039)
|
journal
|
January 2007 |
In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders
|
journal
|
March 2007 |
Synthesis and Pharmacological Characterization of 4-Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of New Potent and Selective Metabotropic Glutamate 2/3 Receptor Agonists
|
journal
|
June 2013 |
Design, Development, and Scale-Up of a Selective meso -Epoxide Desymmetrization Process
|
journal
|
May 2007 |
Säureamid-Reaktionen, L; Orthoamide, I Darstellung und Eigenschaften der Amidacetale und Aminalester
|
journal
|
January 1968 |
Highly enantioselective borane reduction of ketones catalyzed by chiral oxazaborolidines. Mechanism and synthetic implications
|
journal
|
September 1987 |
CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography
|
journal
|
March 2013 |
Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1 S ,2 S ,5 R ,6 S -2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
|
journal
|
February 2015 |
Synthesis and Pharmacological Characterization of C 4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 R ,2 S ,4 R ,5 R ,6 R )-2-Amino-4-(1 H -1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu 2 Receptor Agonist
|
journal
|
September 2015 |
A family of metabotropic glutamate receptors
|
journal
|
January 1992 |
Group III Metabotropic Glutamate Receptors: Pharmacology, Physiology and Therapeutic Potential
|
journal
|
August 2014 |
Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
|
journal
|
February 2007 |
Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist
|
text
|
January 2011 |
In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu 2/3 receptor antagonist
|
journal
|
March 2017 |
mGlu2/3 Agonist-Induced Hyperthermia: An In Vivo Assay for Detection of mGlu2/3 Receptor Antagonism and its Relation to Antidepressant-Like Efficacy in Mice
|
journal
|
July 2013 |