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Title: Methods of identification employing antibody profiles

Patent ·
OSTI ID:1245990

An identification method, applicable to the identification of animals or inanimate objects, is described. The method takes advantage of the set of individual-specific antibodies that are part of the unique antibody repertoire present in animals, by reacting an effective amount of such antibodies with a particular panel, of n-dimensional array (where n is typically one or two) consisting of an effective amount of many different antigens (typically greater than one thousand), to give antibody-antigen complexes. The profile or pattern formed by the antigen-antibody complexes, termed an antibody fingerprint, when revealed by an effective amount of an appropriate detector molecule, is uniquely representative of a particular individual. The method can similarly be used to distinguish genetically, or otherwise similar individuals, or their body parts containing individual-specific antibodies.

Research Organization:
Dicor Technologies, Inc., Lake Forest, CA (United States)
Sponsoring Organization:
USDOE
Assignee:
Dicor Technologies, Inc. (Lake Forest, CA)
Patent Number(s):
5,270,167
Application Number:
07/435,962
OSTI ID:
1245990
Resource Relation:
Patent File Date: 1989 Nov 13
Country of Publication:
United States
Language:
English

References (11)

Cuttings journal October 1981
Demographic study of a wild house sparrow population by DNA fingerprinting journal May 1987
Immunoblotting and dot immunobinding — Current status and outlook journal September 1984
Natural antibodies against tubulin, actin, myoglobin, thyroglobulin, fetuin, albumin and transferrin are present in normal human sera and monoclonal immunoglobulins from multiple myeloma and Waldenström's macroglobulinemia may express similar antibody specificities journal March 1981
Individual-specific ‘fingerprints’ of human DNA journal July 1985
A highly polymorphic locus in human DNA. journal November 1980
Positive identification of an immigration test-case using human DNA fingerprints journal October 1985
Hypervariable ‘minisatellite’ regions in human DNA journal March 1985
Antibody Fingerprinting: A Novel Method for Identifying Individual People and Animals journal July 1988
Forensic application of DNA ‘fingerprints’ journal December 1985
Variable number of tandem repeat (VNTR) markers for human gene mapping journal March 1987

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