Correlation of radiobiological assays of hypoxic fraction with phosphorus-31 magnetic resonance spectroscopy across multiple tumor lines
- Medical College of Wisconsin, Milwaukee, WI (United States)
Hypoxic fractions were measured in multiple tumor models and compared to {sup 31}P magnetic resonance spectroscopy (MRS) parameters. Hypoxic fractions were measured by excision assays in intramuscular and subcutaneous RIF-1 tumors, large and small SCCVII tumors, and KHT tumors. The hypoxic fractions ranged from 3% (small SCCVII) to 21% (KHT). Measurements of {sup 31}P MRS parameters (indices of tumor metabolism) were made under the same conditions used in the hypoxic fraction assays. The PCr/P{sub i} ratios in five tumor models were strongly correlated (r{sup 2}=0.98, {tau} = 1.00, P < 0.02) with their hypoxic fractions, and the NTP/P{sub i} ratio was weakly correlated (r{sup 2} = 0.67, {tau} = 0.60, P < 0.17) with hypoxic fraction. Smaller values of the PCr/P{sub i} and NTP/P{sub i} ratios were found in the tumors with larger hypoxic fractions. These experiments indicate that {sup 31}P MRS may provide a relative measurment of hypoxic fractions across different tumor lines that can be applied non-invasively to individual tumors. 42 refs., 5 figs., 4 tabs.
- OSTI ID:
- 121705
- Journal Information:
- Radiation Research, Vol. 143, Issue 1; Other Information: PBD: Jul 1995
- Country of Publication:
- United States
- Language:
- English
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