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Title: Genetically modified yeast species and fermentation processes using genetically modified yeast

Patent ·
OSTI ID:1020253
 [1];  [2];  [2];  [2];  [3];  [3];  [4];  [5];  [2]
  1. Kingsport, TN
  2. Helsinki, FI
  3. Maple Grove, MN
  4. Cottage Grove, MN
  5. St. Bonifacius, MN
+ Show Author Affiliations

Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications', include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.

Research Organization:
Cargill Inc. (Wayzata, MN)
Sponsoring Organization:
USDOE
DOE Contract Number:
FC07-02ID14349
Assignee:
Cargill Inc. (Wayzata, MN)
Patent Number(s):
7,943,366
Application Number:
10/554,887
OSTI ID:
1020253
Country of Publication:
United States
Language:
English

References (7)

Yeast vectors for integration at the HO locus journal June 2001
Transformation in fungi. journal January 1989
Molecular and industrial aspects of glucose isomerase. journal January 1996
Xylulokinase Overexpression in Two Strains of Saccharomyces cerevisiae Also Expressing Xylose Reductase and Xylitol Dehydrogenase and Its Effect on Fermentation of Xylose and Lignocellulosic Hydrolysate journal September 2001
Amino Acid Substitutions in the Yeast Pichia Stipitis Xylitol Dehydrogenase Coenzyme-Binding Domain Affect the Coenzyme Specificity journal February 1995
High-level functional expression of a fungal xylose isomerase: the key to efficient ethanolic fermentation of xylose by ? journal October 2003
Deletion of the GRE3 Aldose Reductase Gene and Its Influence on Xylose Metabolism in Recombinant Strains of Saccharomyces cerevisiae Expressing the xylA and XKS1 Genes journal December 2001

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