Monitoring genetic damage to ecosystems from hazardous waste
Applications of ecological toxicity testing to hazardous waste management have increased dramatically over the last few years, resulting in a greater awareness of the need for improved biomonitoring techniques. Our laboratory is developing advanced techniques to assess the genotoxic effects of environmental contamination on ecosystems. We have developed a novel mutagenesis assay using the nematode Caenorhabditis elegans, which is potentially applicable for multimedia studies in soil, sediment, and water. In addition, we are conducting validation studies of a previously developed anaphase aberration test that utilizes sea urchin embryos. Other related efforts include field validation studies of the new tests, evaluation of their potential ecological relevance, and analysis of their sensitivity relative to that of existing toxicity tests that assess only lethal effects, rather than genetic damage.
- Research Organization:
- Lawrence Berkeley Lab., CA (United States)
- Sponsoring Organization:
- National Inst. of Environmental Health Sciences, Research Triangle Park, NC (United States)
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 10164229
- Report Number(s):
- LBL-31983; CONF-9204172-1; ON: DE92016922; CNN: Contract NIH P42ES04705-03; Contract 0-137-1220-0
- Resource Relation:
- Conference: Pacific Basin conference on hazardous waste,Bangkok (Thailand),6-10 Apr 1992; Other Information: PBD: Mar 1992
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
54 ENVIRONMENTAL SCIENCES
HAZARDOUS MATERIALS
TOXICITY
GENETIC EFFECTS
ENVIRONMENT
MONITORING
TESTING
VALIDATION
WASTE MANAGEMENT
ECOLOGY
BIOLOGY
RISK ASSESSMENT
DNA
NEMATODES
560300
550200
540220
CHEMICALS METABOLISM AND TOXICOLOGY
BIOCHEMISTRY
CHEMICALS MONITORING AND TRANSPORT