Biochemical and Structural Characterization of the Tautomycetin Thioesterase: Analysis of a Stereoselective Polyketide Hydrolase
Journal Article
·
· Angew. Chem. Int. Ed.
- Michigan
A narrow tunnel: Biochemical and structural analysis of the tautomycetin thioesterase (TE) has provided the first high-resolution structure of a linear-chain-terminating TE in polyketide biosynthesis, showing the enzyme to be stereoselective with a constrained substrate chamber relative to macrolactone-forming thioesterases.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1002844
- Journal Information:
- Angew. Chem. Int. Ed., Vol. 49, Issue (33) ; 08, 2010; ISSN 1433-7851
- Country of Publication:
- United States
- Language:
- ENGLISH
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