DOE Research Contributions
to Radiation and Cancer Therapy
Over the time span of many years, DOE's research has made many contributions to radiation and cancer therapy, including PEREGRINE and Boron Neutron Capture Therapy (BNCT).
'PEREGRINE, a hardware and software system that addresses the problem of radiation therapy dosage using fundamental physics principles, is a revolutionary new tool for analyzing and planning radiation treatment for cancer patients.
About 90 percent of radiation treatment patients receive photon therapy, which is PEREGRINE's principal application. PEREGRINE may also be applied to the less frequently used electron-beam therapy and to brachytherapy, which is radiation therapy from an internally planted radiation source. It is effective for radiography, which predicts the pattern of radiation that is transmitted through a patient or other object.'1
'[B]oron neutron capture therapy (BNCT) [was] first attempted in the United States in the 1950s at Brookhaven National Laboratory. ... In BNCT, the patient consumes a drink containing boron, which is taken up by tumor cells. The tumor then is irradiated with a neutron beam, causing the boron to split into two highly energetic particles that destroy the tumor cells while largely sparing adjacent healthy cells.'2
2 Edited excerpt from Improving Neutron Beams for Cancer Treatment
Additional information about DOE research contributions to radiation and cancer therapy is available in documents and on the Web.
Accelerators for Cancer Therapy, DOE Technical Report, May 2000
Hadron Cancer Therapy: Role of Nuclear Reactions, DOE Technical Report, June 2000
Feasibility of the Utilization of BNCT in the Fast Neutron Therapy Beam at Fermilab, DOE Technical Report, June 2000
Additional Web Pages:
PEREGRINE: Improving Radiation Treatment for Cancer, Lawrence Livermore National Laboratory(LLNL)
Fast Monte Carlo for Radiation Therapy: the PEREGRINE Project
BNCT (Boron Neutron Capture Therapy)
The Clinical State of Boron Neutron Capture Therapy 1997
Neutron Therapy at Fermilab
What is Neutron Therapy?
History of Neutron Therapy
Neutron Therapy Retrospective "The Early Days of Neutron Therapy"
Development of Advanced Multi-Modality Radiation Treatment Planning Software for Neutron Radiotherapy and Beyond